The management of adult aggressive non-Hodgkin's lymphomas

被引：12

作者：

Couderc, B

Dujols, JP

Mokhtari, F

Norkowski, JL

Slawinski, JC

Schlaifer, D

机构：

[1] Grp Radiotherapie & Oncol Med Pyrennes, GROP, F-65000 Tarbes, France

[2] Grp Radiotherapie & Oncol Med Pyrenees, GROP, F-64000 Pau, France

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2000年 / 35卷 / 01期

关键词：

lymphoma; non-Hodgkin's; high-grade; radiotherapy; chemotherapy; review;

D O I：

10.1016/S1040-8428(99)00037-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aggressive non-Hodgkin's lymphoma include diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and different peripheral T-cell lymphomas. An international prognostic index has been developed including age, serum LDH, performance status, and extranodal involvement. For localized aggressive lymphoma, the preferred treatment is 3-4 CHOP and radiation therapy, with a cure rate of 70-80%. For disseminated aggressive lymphoma, current regimens have a cure rate of less than 40%. Innovative strategies, including dose escalation, autologus stem cell support, new drugs, and immunotherapy are being explored to improve these results. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：33 / 48

页数：16

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