Gold(I)-Catalyzed Enantioselective Synthesis of Pyrazolidines, Isoxazolidines, and Tetrahydrooxazines

被引：242

作者：

LaLonde, R. L. ^{[1
]}

Wang, Z. J. ^{[1
]}

Mba, M. ^{[1
]}

Lackner, A. D. ^{[1
]}

Toste, F. Dean ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 03期

关键词：

asymmetric catalysis; gold; heterocycles; hydroamination; pyrazolidines; OPTICALLY-ACTIVE PYRAZOLIDINE; INTRAMOLECULAR HYDROAMINATION; STEREOSELECTIVE-SYNTHESIS; INTERMOLECULAR HYDROAMINATION; ASYMMETRIC HYDROAMINATION; GOLD CATALYSIS; ALLENES; CYCLOISOMERIZATION; HYDROARYLATION; CYCLOADDITION;

D O I：

10.1002/anie.200905000

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) (Figure Presented) Au-ff on a trip: Chiral ligands (L) and chiral anions [(S)-TriPAg] are employed in the gold(I)-catalyzed enantioselective intramolecular additions of hydrazines and hydroxylamines to allenes. These complementary methods allow access to chiral vinyl isoxazolidines, oxazines, and differentially protected pyrazolidines. PNB = para-nitrobenzoyl. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：598 / 601

页数：4

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