Rheumatoid arthritis and smoking: putting the pieces together

被引：126

作者：

Baka, Zsuzsanna ^{[1
]}

Buzas, Edit ^{[1
]}

Nagy, Gyoergy ^{[1
,2
]}

机构：

[1] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1445 Budapest, Hungary

[2] Semmelweis Univ, Dept Rheumatol, H-1023 Budapest, Hungary

来源：

ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 04期

关键词：

CYCLIC CITRULLINATED PEPTIDE; NECROSIS-FACTOR-ALPHA; SHARED EPITOPE ALLELES; NICOTINIC ACETYLCHOLINE-RECEPTOR; GENE-ENVIRONMENT INTERACTIONS; HEAVY CIGARETTE-SMOKING; EPSTEIN-BARR-VIRUS; ALVEOLAR MACROPHAGES; TOBACCO SMOKING; RISK-FACTORS;

D O I：

10.1186/ar2751

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Besides atherosclerosis and lung cancer, smoking is considered to play a major role in the pathogenesis of autoimmune diseases. It has long been known that there is a connection between rheumatoid factor-positive rheumatoid arthritis and cigarette smoking. Recently, an important gene-environment interaction has been revealed; that is, carrying specific HLA-DRB1 alleles encoding the shared epitope and smoking establish a significant risk for anti-citrullinated protein antibody-positive rheumatoid arthritis. We summarize how smoking-related alteration of the cytokine balance, the increased risk of infections (the possibility of cross-reactivity) and modifications of autoantigens by citrullination may contribute to the development of rheumatoid arthritis.

引用

页数：13

共 95 条

[1] Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register [J].

Askling, J. ;

Baecklund, E. ;

Granath, F. ;

Geborek, P. ;

Fored, M. ;

Backlin, C. ;

Bertilsson, L. ;

Coster, L. ;

Jacobsson, L. T. ;

Lindblad, S. ;

Lysholm, J. ;

Rantapaa-Dahlqvist, S. ;

Saxne, T. ;

van Vollenhoven, R. ;

Klareskog, L. ;

Feltelius, N. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (05) :648-653

[2] Tumor necrosis factor-alpha and Interleukin-10 gene promoter polymorphisms in Turkish rheumatoid arthritis patients [J].

Ates, Omer ;

Hatemi, Gulen ;

Hamuryudan, Vedat ;

Topal-Sarikaya, Aysegul .

CLINICAL RHEUMATOLOGY, 2008, 27 (10) :1243-1248

[3] Anti-cyclic citrullinated peptide antibodies in primary Sjogren syndrome may be associated with non-erosive synovitis [J].

Atzeni, Fabiola ;

Sarzi-Puttini, Piercarlo ;

Lama, Nicola ;

Bonacci, Eleonora ;

Bobbio-Pallavicini, Francesca ;

Montecucco, Carlomaurizio ;

Caporali, Roberto .

ARTHRITIS RESEARCH & THERAPY, 2008, 10 (03)

[4] THE ANTIESTROGENIC EFFECT OF CIGARETTE-SMOKING IN WOMEN [J].

BARON, JA ;

LAVECCHIA, C ;

LEVI, F .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 162 (02) :502-514

[5] A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis [J].

Begovich, AB ;

Carlton, VEH ;

Honigberg, LA ;

Schrodi, SJ ;

Chokkalingam, AP ;

Alexander, HC ;

Ardlie, KG ;

Huang, QQ ;

Smith, AM ;

Spoerke, JM ;

Conn, MT ;

Chang, M ;

Chang, SYP ;

Saiki, RK ;

Catanese, JJ ;

Leong, DU ;

Garcia, VE ;

McAllister, LB ;

Jeffery, DA ;

Lee, AT ;

Batliwalla, F ;

Remmers, E ;

Criswell, LA ;

Seldin, MF ;

Kastner, DL ;

Amos, CI ;

Sninsky, JJ ;

Gregersen, PK .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (02) :330-337

[6] Modulation of the primary and the secondary antibody response by tobacco smoke condensates [J].

Van Binh, PN ;

Zhou, D ;

Baudouin, F ;

Martin, C ;

Radionoff, M ;

Dutertre, H ;

Marchand, V ;

Thevenin, M ;

Warnet, JM ;

Duc, HT .

BIOMEDICINE & PHARMACOTHERAPY, 2004, 58 (09) :527-530

[7] Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies - Systematic review and meta-analysis of rare harmful effects in randomized controlled trials [J].

Bongartz, T ;

Sutton, AJ ;

Sweeting, MJ ;

Buchan, I ;

Matteson, EL ;

Montori, V .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (19) :2275-2285

[8] Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin [J].

Borovikova, LV ;

Ivanova, S ;

Zhang, MH ;

Yang, H ;

Botchkina, GI ;

Watkins, LR ;

Wang, HC ;

Abumrad, N ;

Eaton, JW ;

Tracey, KJ .

NATURE, 2000, 405 (6785) :458-462

[9] Recent advances in the genetics of RA susceptibility [J].

Bowes, J. ;

Barton, A. .

RHEUMATOLOGY, 2008, 47 (04) :399-402

[10]

Bueno Clara, 2007, Chem Immunol Allergy, V93, P161, DOI 10.1159/000100894

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