Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood

被引：856

作者：

Anacker, Christoph ^{[1
,2
]}

Hen, Rene ^{[1
,3
,4
]}

机构：

[1] Columbia Univ, Dept Psychiat, New York, NY 10032 USA

[2] New York State Psychiat Inst & Hosp, Res Fdn Mental Hyg, 1051 Riverside Dr, New York, NY 10032 USA

[3] Columbia Univ, Dept Neurosci, 40 Haven Ave, New York, NY 10032 USA

[4] Columbia Univ, Dept Pharmacol, 630 West 168th St, New York, NY 10032 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2017年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ANTAGONIST MIFEPRISTONE NORMALIZES; OBSESSIVE-COMPULSIVE DISORDER; SPATIAL-PATTERN SEPARATION; DEPRESSION-LIKE BEHAVIORS; ANXIETY-RELATED BEHAVIORS; NEURAL PROGENITOR CELLS; DENTATE GRANULE CELLS; VENTRAL HIPPOCAMPUS; DORSOVENTRAL AXIS; ANTIDEPRESSANT TREATMENT;

D O I：

10.1038/nrn.2017.45

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Adult hippocampal neurogenesis has been implicated in cognitive processes, such as pattern separation, and in the behavioural effects of stress and antidepressants. Young adult-born neurons have been shown to inhibit the overall activity of the dentate gyrus by recruiting local interneurons, which may result in sparse contextual representations and improved pattern separation. We propose that neurogenesis-mediated inhibition also reduces memory interference and enables reversal learning both in neutral situations and in emotionally charged ones. Such improved cognitive flexibility may in turn help to decrease anxiety-like and depressive-like behaviour.

引用

收藏

页码：335 / 346

页数：12

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