Viral manipulation of DNA repair and cell cycle checkpoints

被引：115

作者：

Chaurushiya, Mira S. ^{[1
,2
]}

Weitzman, Matthew D. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Div Biol, Grad Program, San Diego, CA 92093 USA

来源：

DNA REPAIR | 2009年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Viruses; Cancer; Transformation; Checkpoints; Cell cycle; EPSTEIN-BARR-VIRUS; DEPENDENT PROTEIN-KINASE; DOUBLE-STRAND BREAKS; HTLV-I TAX; LARGE-T-ANTIGEN; SPINDLE ASSEMBLY CHECKPOINT; ANAPHASE-PROMOTING-COMPLEX; ADENOVIRUS E4ORF4 PROTEIN; PAPILLOMAVIRUS TYPE-16 E6; HUMAN SOMATIC-CELLS;

D O I：

10.1016/j.dnarep.2009.04.016

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Recognition and repair of DNA damage is critical for maintaining genomic integrity and suppressing tumorigenesis. In eukaryotic cells, the sensing and repair of DNA damage are coordinated with cell cycle progression and checkpoints, in order to prevent the propagation of damaged DNA. The carefully maintained cellular response to DNA damage is challenged by viruses, which produce a large amount of exogenous DNA during infection. Viruses also express proteins that perturb cellular DNA repair and cell cycle pathways, promoting tumorigenesis in their quest for cellular domination. This review presents an overview of strategies employed by viruses to manipulate DNA damage responses and cell cycle checkpoints as they commandeer the cell to maximize their own viral replication. Studies of viruses have identified key cellular regulators and revealed insights into molecular mechanisms governing DNA repair, cell cycle checkpoints, and transformation. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1166 / 1176

页数：11

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