Comparison of the efficacy of cell preparations from embryonic ventral mesencephalon of various prenatal age transplanted intrastriatally to rats with 6-OHDA-induced parkinsonism

被引：1

作者：

Chekhonin, VP ^{[1
]}

Lebedev, SV ^{[1
]}

Dmitrieva, TB ^{[1
]}

Blinov, DV ^{[1
]}

Lazarenko, IP ^{[1
]}

Savchenko, EA ^{[1
]}

Volodin, NN ^{[1
]}

机构：

[1] VP Serbskii State Res Ctr Social & Forens Psychia, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 06期

关键词：

rat; 6-OHDA-hemiparkinsonism; preparations of embryonic nervous tissue; apomorphine-induced motor asymmetry; dopaminergic neurons;

D O I：

10.1023/A:1020258531077

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis of apornorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy of cell preparations from 8- and lower from 16-17-day-old embryos. These data correlated with histomorphological findigs, in particular, with the size of grafts, glial reaction, and the number of dopaminergic neurons in the grafts.

引用

页码：609 / 613

页数：5

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