Cytokines and neuro-immune-endocrine interactions:: a role for the hypothalamic-pituitary-adrenal revolving axis

被引:328
作者
Haddad, JJ
Saadé, NE
Safieh-Garabedian, B
机构
[1] Univ Calif San Francisco, Severinghaus Radiometer Res Labs, Mol Neurosci Res Div, Dept Anesthesia & Perioperat Care,Sch Med, San Francisco, CA 94143 USA
[2] Amer Univ Beirut, Fac Med, Dept Human Morphol, Div Mol & Behav Neurosci Res, Beirut 110236, Lebanon
[3] Amer Univ Beirut, Fac Med, Dept Physiol, Div Mol & Behav Neurosci Res, Beirut 110236, Lebanon
[4] Amer Univ Beirut, Fac Arts & Sci, Dept Biol, Beirut 110236, Lebanon
基金
英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院;
关键词
brain; CNS; cytokine; HPA; inflammation; neuroimmunology; neuropeptide; neurotransmitters; oxidative stress; transcription;
D O I
10.1016/S0165-5728(02)00357-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cytokines, peptide hormones and neurotransmitters, as well as their receptors/ligands, are endogenous to the brain, endocrine and immune systems. These shared ligands and receptors are used as a common chemical language for communication within and between the immune and neuroendocrine systems. Such communication suggests an immunoregulatory role for the brain and a sensory function for the immune system. Interplay between the immune, nervous and endocrine systems is most commonly associated with the pronounced effects of stress on immunity. The hypothalamic-pituitary-adrenal (HPA) axis is the key player in stress responses; it is well established that both external and internal stressors activate the HPA axis. Cytokines are chemical messengers that stimulate the HPA axis when the body is under stress or experiencing an infection. This review discusses current knowledge of cytokine signaling pathways in neuro-immune-endocrine interactions as viewed through the triplet HPA axis. In addition, we elaborate on HPA/cytokine interactions in oxidative stress within the context of nuclear factor-kappaB transcriptional regulation and the role of oxidative markers and related gaseous transmitters. (C) 2002 Elsevier Science B.V All rights reserved.
引用
收藏
页码:1 / 19
页数:19
相关论文
共 138 条
[1]  
Anforth HR, 1998, EUR CYTOKINE NETW, V9, P279
[2]   EFFECT OF INTERLEUKIN-1-BETA ON PLASMA ACTH, BETA-ENDORPHIN, AND CORTICOSTERONE LEVELS IN INFANT AND PREPUBERTAL RATS [J].
BARNA, I ;
ACS, Z ;
BUGOVICS, G ;
KOENIG, JI .
PEDIATRIC RESEARCH, 1995, 37 (06) :714-719
[3]   CORTICOSTEROID REGULATION OF IL-1 RECEPTORS IN THE MOUSE HIPPOCAMPUS - EFFECTS OF GLUCOCORTICOID TREATMENT, STRESS, AND ADRENALECTOMY [J].
BETANCUR, C ;
LLEDO, A ;
BORRELL, J ;
GUAZA, C .
NEUROENDOCRINOLOGY, 1994, 59 (02) :120-128
[4]   CYTOKINE REGULATION OF CORTICOSTEROID RECEPTORS IN THE RAT HIPPOCAMPUS - EFFECTS OF INTERLEUKIN-1, INTERLEUKIN-6, TUMOR-NECROSIS-FACTOR AND LIPOPOLYSACCHARIDE [J].
BETANCUR, C ;
BORRELL, J ;
GUAZA, C .
NEUROENDOCRINOLOGY, 1995, 62 (01) :47-54
[5]  
Boraschi Diana, 1998, European Cytokine Network, V9, P205
[6]   Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin [J].
Borovikova, LV ;
Ivanova, S ;
Zhang, MH ;
Yang, H ;
Botchkina, GI ;
Watkins, LR ;
Wang, HC ;
Abumrad, N ;
Eaton, JW ;
Tracey, KJ .
NATURE, 2000, 405 (6785) :458-462
[7]   INTERLEUKIN-1 PREVENTS LOSS OF CORTICOTROPIC RESPONSIVENESS TO BETA-ADRENERGIC STIMULATION INVITRO [J].
BOYLE, M ;
YAMAMOTO, G ;
CHEN, M ;
RIVIER, J ;
VALE, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) :5556-5560
[8]   Gaseous transmitters and neuroendocrine regulation [J].
Brann, DW ;
Bhat, GK ;
Lamar, CA ;
Mahesh, VB .
NEUROENDOCRINOLOGY, 1997, 65 (06) :385-395
[9]   SUPPRESSION OF SPLENIC MACROPHAGE INTERLEUKIN-1 SECRETION FOLLOWING INTRACEREBROVENTRICULAR INJECTION OF INTERLEUKIN-1-BETA - EVIDENCE FOR PITUITARY-ADRENAL AND SYMPATHETIC CONTROL [J].
BROWN, R ;
LI, Z ;
VRIEND, CY ;
NIRULA, R ;
JANZ, L ;
FALK, J ;
NANCE, DM ;
DYCK, DG ;
GREENBERG, AH .
CELLULAR IMMUNOLOGY, 1991, 132 (01) :84-93
[10]  
BRUNETTI L, 1994, LIFE SCI, V54, P165