ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates

被引：99

作者：

Endimiani, Andrea ^{[1
,2
]}

Hujer, Kristine M. ^{[1
,2
]}

Hujer, Andrea M. ^{[1
]}

Armstrong, Eliana S. ^{[3
]}

Choudhary, Yuvraj ^{[1
]}

Aggen, James B.

Bonomo, Robert A. ^{[1
,2
,4
,5
]}

机构：

[1] Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Res Serv, Cleveland, OH USA

[2] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA

[3] Achaogen Inc, San Francisco, CA USA

[4] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Dept Mol Biol & Microbiol, Sch Med, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 10期

基金：

美国国家卫生研究院;

关键词：

AMINOGLYCOSIDE ACTION; POLYMYXIN-B; SUSCEPTIBILITY; PREVALENCE; GENES;

D O I：

10.1128/AAC.00556-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The in vitro activity of ACHN-490, a novel aminoglycoside ("neoglycoside"), was evaluated against 102 multidrug-resistant (MDR) Klebsiella pneumoniae strains, including a subset of 25 strains producing the KPC carbapenemase. MIC50 values for gentamicin, tobramycin, and amikacin were 8 mu g/ml, 32 mu g/ml, and 2 mu g/ml, respectively; MIC90 values for the same antimicrobials were >= 64 mu g/ml, >= 64 mu g/ml, and 32 mu g/ml, respectively. ACHN-490 showed an MIC50 of 0.5 mu g/ml and an MIC90 of 1 mu g/ml, which are significantly lower than those of comparator aminoglycosides. ACHN-490 represents a promising aminoglycoside for the treatment of MDR K. pneumoniae isolates, including those producing KPC beta-lactamase.

引用

页码：4504 / 4507

页数：4

共 23 条

[1]

Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY:: molecular epidemiology and in vitro activity of polymyxin B and other agents [J].

Bratu, S ;

Tolaney, P ;

Karumudi, U ;

Quale, J ;

Mooty, M ;

Nichani, S ;

Landman, D .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (01) :128-132

[2]

Clinical and Laboratory Standards Institute, 2018, METH DIL ANT SUSC TE

[3]

CLSI Clinical and Laboratory Standards Institute, 2008, CLSI document M100-S18

[4]

16S ribosomal RNA methylation: Emerging resistance mechanism against aminoglycosides [J].

Doi, Yohei ;

Arakawa, Yoshichika .

CLINICAL INFECTIOUS DISEASES, 2007, 45 (01) :88-94

[5]

Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA [J].

Endimiani, Andrea ;

Hujer, Andrea M. ;

Perez, Federico ;

Bethel, Christopher R. ;

Hujer, Kristine M. ;

Kroeger, Jennifer ;

Oethinger, Margret ;

Paterson, David L. ;

Adams, Mark D. ;

Jacobs, Michael R. ;

Diekema, Daniel J. ;

Hall, Gerri S. ;

Jenkins, Stephen G. ;

Rice, Louis B. ;

Tenover, Fred C. ;

Bonomo, Robert A. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 63 (03) :427-437

[6]

Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States [J].

Endimiani, Andrea ;

Carias, Lenore L. ;

Hujer, Andrea M. ;

Bethel, Christopher R. ;

Hujer, Kristine M. ;

Perez, Federico ;

Hutton, Rebecca A. ;

Fox, William R. ;

Hall, Geraldine S. ;

Jacobs, Michael R. ;

Paterson, David L. ;

Rice, Louis B. ;

Jenkins, Stephen G. ;

Tenover, Fred C. ;

Bonomo, Robert A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (07) :2680-2682

[7]

Detection of Plasmid-Mediated KPC-Producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of Intrahospital Transmission [J].

Goldfarb, David ;

Harvey, Sarah-Beth ;

Jessamine, Kelsi ;

Jessamine, Peter ;

Toye, Baldwin ;

Desjardins, Marc .

JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (06) :1920-1922

[8]

Prevalence and antimicrobial susceptibility data for extended-spectrum β-lactamase- and AmpC-producing Enterobacteriaceae from the MYSTIC Program in Europe and the United States (1997-2004) [J].

Goossens, H ;

Grabein, B .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2005, 53 (04) :257-264

[9]

Regional variation in the prevalence of extended-spectrum β-lactamase-producing clinical isolates in the Asia-Pacific region (SENTRY 1998-2002) [J].

Hirakata, Y ;

Matsuda, J ;

Miyazaki, Y ;

Kamihira, S ;

Kawakami, S ;

Miyazawa, Y ;

Ono, Y ;

Nakazaki, N ;

Hirata, Y ;

Inoue, M ;

Turnidge, JD ;

Bell, JM ;

Jones, RN ;

Kohno, S .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2005, 52 (04) :323-329

[10]

Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp isolates from military and civilian patients treated at the Walter Reed Army Medical Center [J].

Hujer, Kristine M. ;

Hujer, Andrea M. ;

Hulten, Edward A. ;

Bajaksouzian, Saralee ;

Adams, Jennifer M. ;

Donskey, Curtis J. ;

Ecker, David J. ;

Massire, Christian ;

Eshoo, Mark W. ;

Sampath, Rangarajan ;

Thomson, Jodi M. ;

Rather, Philip N. ;

Craft, David W. ;

Fishbain, Joel T. ;

Ewell, Allesa J. ;

Jacobs, Michael R. ;

Paterson, David L. ;

Bonomo, Robert A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (12) :4114-4123

← 1 2 3 →