Four new cytotoxic germacranolides from Carpesium divaricatum

被引：45

作者：

Kim, DK ^{[1
]}

Baek, NI ^{[1
]}

Choi, SU ^{[1
]}

Lee, CO ^{[1
]}

Lee, KR ^{[1
]}

Zee, OP ^{[1
]}

机构：

[1] SUNGKYUNKWAN UNIV, COLL PHARM, NATL PROD LAB, JANGAN KU, SUWON 440746, SOUTH KOREA

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 11期

关键词：

D O I：

10.1021/np970157d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In a bioassay-guided search far cytotoxic compounds from higher plants of South Korea, four new sesquiterpenes of the germacranolide type, named cardivins A (1), B (2), C (3), and D (4), have been isolated from the aerial parts of Carpesium divaricatum. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds 1, 2, 3, and 4 showed cytotoxicity to the human tumor cells, A-549 (nonsmallcell lung), SK-OV-3 (ovary), SK-MEL-2 (skin), XF-498 (central nervous system), and HCT-15 (colon).

引用

页码：1199 / 1202

页数：4

共 11 条

[1] UNUSUAL GERMACRANOLIDES FROM INULA-EUPATORIOIDES
BARUAH, RN
SHARMA, RP
THYAGARAJAN, G
HERZ, W
GOVINDAN, SV
BLOUNT, JF
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (24) : 4838 - 4843
[2] SESQUITERPENE LACTONES FROM CARPESIUM-DIVARICATUM
MARUYAMA, M
[J]. PHYTOCHEMISTRY, 1990, 29 (02) : 547 - 550
[3] INEUPATOROLIDES FROM CARPESIUM-GLOSSOPHYLLUM
MARUYAMA, M
WATANABE, K
KAWAKAMI, T
MAEDA, M
KATO, M
NOZOE, S
OHTA, T
[J]. PLANTA MEDICA, 1995, 61 (04) : 388 - 389
[4] STEREOCHEMISTRY OF GRANILIN ISOLATED FROM CARPESIUM-ABROT ANOIDES
MARUYAMA, M
SHIBATA, F
[J]. PHYTOCHEMISTRY, 1975, 14 (10) : 2247 - 2248
[5] SESQUITERPENE LACTONES FROM CARPESIUM-ABROTANOIDES
MARUYAMA, M
KARUBE, A
SATO, K
[J]. PHYTOCHEMISTRY, 1983, 22 (12) : 2773 - 2774
[6] CARPESIOLIN FROM CARPESIUM-ABROTANOIDES
MARUYAMA, M
OMURA, S
[J]. PHYTOCHEMISTRY, 1977, 16 (06) : 782 - 783
[7] OKUNADE AL, 1990, PHYTOCHEMISTRY, V29, P547
[8] COMPARISON OF INVITRO ANTICANCER-DRUG-SCREENING DATA GENERATED WITH A TETRAZOLIUM ASSAY VERSUS A PROTEIN ASSAY AGAINST A DIVERSE PANEL OF HUMAN TUMOR-CELL LINES
RUBINSTEIN, LV
SHOEMAKER, RH
PAULL, KD
SIMON, RM
TOSINI, S
SKEHAN, P
SCUDIERO, DA
MONKS, A
BOYD, MR
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) : 1113 - 1118
[9] Ryu Shi Yong, 1992, Archives of Pharmacal Research (Seoul), V15, P356, DOI 10.1007/BF02974112
[10] NEW COLORIMETRIC CYTOTOXICITY ASSAY FOR ANTICANCER-DRUG SCREENING
SKEHAN, P
STORENG, R
SCUDIERO, D
MONKS, A
MCMAHON, J
VISTICA, D
WARREN, JT
BOKESCH, H
KENNEY, S
BOYD, MR
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (13) : 1107 - 1112

← 1 2 →