Diverse Effects of Statins on Angiogenesis: New Therapeutic Avenues

被引：55

作者：

Elewa, Hazem F. ^{[2
,3
]}

El-Remessy, Azza B. ^{[2
,3
]}

Somanath, Payaningal R. ^{[2
,3
]}

Fagan, Susan C. ^{[1
,2
,3
]}

机构：

[1] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

[2] Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Augusta, GA USA

[3] Charlie Norwood Vet Adm Med Ctr, Specialty Care Serv Line, Augusta, GA USA

来源：

PHARMACOTHERAPY | 2010年 / 30卷 / 02期

基金：

美国国家卫生研究院;

关键词：

angiogenesis; 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors; HMG-CoA; statins; stroke; myocardial infarction; diabetic retinopathy; cancer; HMG-COA REDUCTASE; ENDOTHELIAL GROWTH-FACTOR; DIABETIC-RETINOPATHY; CEREBRAL-ISCHEMIA; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; EMBOLIC STROKE; PHASE-I; SIMVASTATIN; ATORVASTATIN;

D O I：

10.1592/phco.30.2.169

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Angiogenesis is an important process for a variety of physiologic and pathologic conditions. Different angiogenic modulating targets are under extensive investigation both experimentally and clinically The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are the first-line agents used in hypercholesterolemia. They are also characterized by having other benefits apart from their lipid-lowering effects. Among these pleiotropic effects are the pro- and antiangiogenic properties of statins. The pleiotropic effects of statins and how they modulate new blood vessel formation are discussed in this review. The currently available data from both animal and human studies regarding the effects of statins on angiogenesis in ischemic heart disease, stroke, ocular diseases, and cancer are also reviewed. Statins are safe, orally available agents that may acquire novel therapeutic indications through their angiogenic modulating effects.

引用

页码：169 / 176

页数：8

共 73 条

[1] Role of NADPH oxidase and stat3 in statin-mediated protection against diabetic retinopathy [J].

Al-Shabrawey, Mohamed ;

Bartoli, Manuela ;

El-Remessy, Azza B. ;

Ma, Guochuan ;

Matragoon, Suraporn ;

Lemtalsi, Tahira ;

Caldwell, R. William ;

Caldwell, Ruth B. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2008, 49 (07) :3231-3238

[2] Diabetic Retinopathy: Current Management and Experimental Therapeutic Targets [J].

Ali, Tayyeba K. ;

El-Remessy, Azza B. .

PHARMACOTHERAPY, 2009, 29 (02) :182-192

[3]

Amarenco P, 2006, NEW ENGL J MED, V355, P549

[4] Short-term efficacy of intravitreal bevacizumab for the treatment of macular edema due to diabetic retinopathy and retinal vein occlusion [J].

Astam N. ;

Batioǧlu F. ;

Özmert E. .

International Ophthalmology, 2009, 29 (5) :343-348

[5] The Role of Vascular Endothelial Growth Factor in Wound Healing [J].

Bao, Philip ;

Kodra, Arber ;

Tomic-Canic, Marjana ;

Golinko, Michael S. ;

Ehrlich, H. Paul ;

Brem, Harold .

JOURNAL OF SURGICAL RESEARCH, 2009, 153 (02) :347-358

[6] HMG-CoA Reductase Inhibitors (Statin) Prevents Retinal Neovascularization in a Model of Oxygen-Induced Retinopathy [J].

Bartoli, Manuela ;

Al-Shabrawey, Mohamed ;

Labazi, Mohamed ;

Behzadian, M. Ali ;

Istanboli, Mohamed ;

El-Remessy, Azza B. ;

Caldwell, Robert W. ;

Marcus, Dennis M. ;

Caldwell, Ruth B. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009, 50 (10) :4934-4940

[7] Effects of erythropoietin after an acute myocardial infarction: Rationale and study design of a prospective, randomized, clinical trial (HEBE III) [J].

Belonje, Anne M. ;

Voors, Adriaan A. ;

van Gilst, Wiek H. ;

Anker, Stefan D. ;

Slart, Riemer H. ;

Tio, Rene A. ;

Zijlstra, Felix ;

van Veldhuisen, Dirk J. .

AMERICAN HEART JOURNAL, 2008, 155 (05) :817-822

[8] Effects of angiogenesis inhibitors on multistage carcinogenesis in mice [J].

Bergers, G ;

Javaherian, K ;

Lo, KM ;

Folkman, J ;

Hanahan, D .

SCIENCE, 1999, 284 (5415) :808-812

[9] Vascular endothelial growth factor and diabetic retinopathy: Role of oxidative stress [J].

Caldwell, RB ;

Bartoli, M ;

Behzadian, MA ;

El-Remessy, AEB ;

Al-Shabrawey, M ;

Platt, DH ;

Liou, GI ;

Caldwell, RW .

CURRENT DRUG TARGETS, 2005, 6 (04) :511-524

[10] A review of Judah Folkman's remarkable achievements in biomedicine [J].

Cao, Yihai ;

Langer, Robert .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (36) :13203-13205

← 1 2 3 4 5 6 7 8 →