RTN TRH causes prolonged respiratory stimulation

被引:17
作者
Cream, CL [1 ]
Li, AH [1 ]
Nattie, EE [1 ]
机构
[1] DARTMOUTH COLL,SCH MED,DEPT PHYSIOL,LEBANON,NH 03756
关键词
control of breathing; ventrolateral medulla; thyrotropin-releasing hormone free acid; histidine-proline diketopiperazine; blood pressure; respiratory regulation; retrotrapezoid nucleus;
D O I
10.1152/jappl.1997.83.3.792
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We injected thyrotropin-releasing hormone (TRH; 10 nl; 0.25, 0.5, 1.0, or 10 mM), its inactive free acid form (TRHOH; 1 mM), or a metabolite with low TRH-receptor binding affinity, histidine-proline diketopiperazine (cHP; 1 mM), into the retrotrapezoid nucleus of anesthetized rats. Injection location was verified by anatomic analysis. Lower doses (0.25-0.5 mM) significantly increased both the product of integrated phrenic amplitude and frequency (integral Phr.f) and f for 20-30 min compared with artificial cerebrospinal fluid control injections. Higher doses (1.0-10 mM) produced greater and long-lasting stimulation of integral Phr.f, integral Phr, and f and of blood pressure. This stimulation reached values 150% of baseline and durations of 270 min after a single injection. TRHOH (1 mM) or cHP (1 mM) had no effect on integral Phr but increased f, as did 1 mM TRH. We conclude that TRH has a very powerful stimulatory effect in the retrotrapezoid nucleus region on integral Phr.f, with the integral Phr response seemingly specific for TRH receptors. Similar responses of f to TRHOH and cHP suggest it may be nonspecific.
引用
收藏
页码:792 / 799
页数:8
相关论文
共 30 条
[1]   Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats [J].
Akilesh, MR ;
Kamper, M ;
Li, AH ;
Nattie, EE .
JOURNAL OF APPLIED PHYSIOLOGY, 1997, 82 (02) :469-479
[2]  
BAYLISS DA, 1994, J NEUROSCI, V14, P821
[3]   LOCAL-EFFECTS OF SUBSTANCE-P ON RESPIRATORY REGULATION IN THE RAT MEDULLA-OBLONGATA [J].
CHEN, ZB ;
HEDNER, J ;
HEDNER, T .
JOURNAL OF APPLIED PHYSIOLOGY, 1990, 68 (02) :693-699
[4]   THE TIME COURSE OF GLUTAMATE IN THE SYNAPTIC CLEFT [J].
CLEMENTS, JD ;
LESTER, RAJ ;
TONG, G ;
JAHR, CE ;
WESTBROOK, GL .
SCIENCE, 1992, 258 (5087) :1498-1501
[5]   WIDESPREAD SITES OF BRAIN-STEM VENTILATORY CHEMORECEPTORS [J].
COATES, EL ;
LI, AH ;
NATTIE, EE .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 75 (01) :5-14
[6]   THYROTROPIN-RELEASING-HORMONE INDUCES RHYTHMIC BURSTING IN NEURONS OF THE NUCLEUS TRACTUS SOLITARIUS [J].
DEKIN, MS ;
RICHERSON, GB ;
GETTING, PA .
SCIENCE, 1985, 229 (4708) :67-69
[7]   LOCALIZATION OF IMMUNOREACTIVE THYROTROPIN RELEASING HORMONE IN THE LOWER BRAIN-STEM OF THE RAT [J].
ESKAY, RL ;
LONG, RT ;
PALKOVITS, M .
BRAIN RESEARCH, 1983, 277 (01) :159-162
[8]   EFFECTS ON BREATHING OF VENTROLATERAL MEDULLARY COOLING IN AWAKE GOATS [J].
FORSTER, HV ;
OHTAKE, PJ ;
PAN, LG ;
LOWRY, TF ;
KORDUCKI, MJ ;
AARON, HA ;
FORSTER, AI .
JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (01) :258-265
[9]   DEVELOPMENT OF THYROTROPIN-RELEASING-HORMONE AND NOREPINEPHRINE POTENTIATION OF INSPIRATORY-RELATED HYPOGLOSSAL MOTONEURON DISCHARGE IN NEONATAL AND JUVENILE MICE IN-VITRO [J].
FUNK, GD ;
SMITH, JC ;
FELDMAN, JL .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (05) :2538-2541
[10]   Thyrotropin-releasing hormone stimulates perinatal rat respiration in vitro [J].
Greer, JJ ;
AlZubaidy, Z ;
Carter, JE .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1996, 271 (05) :R1160-R1164