Serial measurements of N-terminal pro-brain natriuretic peptide after acute ischemic stroke

被引：41

作者：

Jensen, J. K. ^{[1
]}

Mickley, H.

Bak, S.

Korsholm, L.

Kristensen, S. R.

机构：

[1] Odense Univ Hosp, Dept Cardiol, DK-5000 Odense C, Denmark

[2] Odense Univ Hosp, Dept Neurol, DK-5000 Odense C, Denmark

[3] Univ So Denmark, Dept Stat, Odense, Denmark

[4] Aarhus Univ Hosp, Aalborg Hosp, Cardiovasc Res Ctr, Dept Clin Biochem, Aalborg, Denmark

来源：

CEREBROVASCULAR DISEASES | 2006年 / 22卷 / 5-6期

关键词：

ischemic stroke; N-terminal pro-brain natriuretic peptide; time-course; prognosis;

D O I：

10.1159/000094997

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The exact time-course of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the prognostic importance in the immediate phase of ischemic stroke have not been established. Methods: NT-proBNP was measured daily from admission to day 5 and again at 6-month follow-up in 250 consecutive patients with acute ischemic stroke. Results: NT-proBNP peaked the day after onset of symptoms (p = 0.007) followed by a decrease until day 5 (p = 0.001, ANOVA). At 6-month follow-up the difference in the level of NT-proBNP was unchanged compared to day 5 (p = 0.42). NT-proBNP levels >= 615 pg/ml at day 2 after onset of symptoms was associated with 6-month mortality. Conclusion: NT-proBNP peaks the day after onset of symptoms in patients with acute ischemic stroke. A single measurement of NT-proBNP appears to be an indicator of 6-month mortality. Copyright (c) 2006 S. Karger AG, Basel.

引用

页码：439 / 444

页数：6

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