Cytokines regulate c-Met expression in cultured astrocytes

被引：14

作者：

Shimazaki, K ^{[1
]}

Yoshida, K ^{[1
]}

Hirose, Y ^{[1
]}

Ishimori, H ^{[1
]}

Katayama, M ^{[1
]}

Kawase, T ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Neurosurg, Tokyo 1608582, Japan

来源：

BRAIN RESEARCH | 2003年 / 962卷 / 1-2期

关键词：

c-Met; astrocyte; regeneration; RT-PCR; Western blot analysis; double immunofluorescent staining;

D O I：

10.1016/S0006-8993(02)03975-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. Reverse transcription-polymerase chain reaction revealed that FGFs and HGF enhanced c-met expression. These findings suggest that c-Met expressed in astrocytes may have important roles during the nervous system regeneration. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：105 / 110

页数：6

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