RNA polymerase II holoenzyme and transcriptional regulation

被引：87

作者：

Greenblatt, J ^{[1
]}

机构：

[1] UNIV TORONTO, DEPT MED & MOL GENET, TORONTO, ON M5G 1L6, CANADA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1997年 / 9卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0955-0674(97)80002-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNA polymerase II holoenzymes isolated from yeast and mammalian cells are large, preassembled complexes that contain some or all of the general transcription initiation factors and many other polypeptides. Recent experiments suggest that these holoenzymes may mediate alterations in chromatin structure and play a key role in regulatory mechanisms that influence transcriptional initiation, RNA chain elongation, RNA processing and transcription termination.

引用

页码：310 / 319

页数：10

共 78 条

[1] Distinct activated and non-activated RNA polymerase II complexes in yeast [J].

Akhtar, A ;

Faye, G ;

Bentley, DL .

EMBO JOURNAL, 1996, 15 (17) :4654-4664

[2] MUTATIONS IN RNA POLYMERASE-II ENHANCE OR SUPPRESS MUTATIONS IN GAL4 [J].

ALLISON, LA ;

INGLES, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2794-2798

[3] Yeast TAF(II)90 is required for cell-cycle progression through G(2)/M but not for general transcription activation [J].

Apone, LM ;

Virbasius, CMA ;

Reese, JC ;

Green, MR .

GENES & DEVELOPMENT, 1996, 10 (18) :2368-2380

[4] 3 SUBUNITS OF THE RNA-POLYMERASE-II MEDIATOR COMPLEX ARE INVOLVED IN GLUCOSE REPRESSION [J].

BALCIUNAS, D ;

RONNE, H .

NUCLEIC ACIDS RESEARCH, 1995, 23 (21) :4421-4425

[5] CONTACT WITH A COMPONENT OF THE POLYMERASE-II HOLOENZYME SUFFICES FOR GENE ACTIVATION [J].

BARBERIS, A ;

PEARLBERG, J ;

SIMKOVICH, N ;

FARRELL, S ;

REINAGEL, P ;

BAMDAD, C ;

SIGAL, G ;

PTASHNE, M .

CELL, 1995, 81 (03) :359-368

[6] REGULATION OF TRANSCRIPTIONAL ELONGATION BY RNA-POLYMERASE-II [J].

BENTLEY, DL .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1995, 5 (02) :210-216

[7] GENETIC ISOLATION OF ADA2 - A POTENTIAL TRANSCRIPTIONAL ADAPTER REQUIRED FOR FUNCTION OF CERTAIN ACIDIC ACTIVATION DOMAINS [J].

BERGER, SL ;

PINA, B ;

SILVERMAN, N ;

MARCUS, GA ;

AGAPITE, J ;

REGIER, JL ;

TRIEZENBERG, SJ ;

GUARENTE, L .

CELL, 1992, 70 (02) :251-265

[8] Mediator of transcriptional regulation [J].

Bjorklund, S ;

Kim, YJ .

TRENDS IN BIOCHEMICAL SCIENCES, 1996, 21 (09) :335-337

[9]

Blau J, 1996, MOL CELL BIOL, V16, P2044

[10] Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation [J].

Brownell, JE ;

Allis, CD .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (02) :176-184

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