The sex ratio of singleton offspring in assisted-conception pregnancies

被引:41
作者
Luke, Barbara [1 ,2 ]
Brown, Morton B. [3 ]
Grainger, David A. [4 ]
Baker, Valerie L. [5 ]
Ginsburg, Elizabeth [6 ]
Stern, Judy E. [7 ]
机构
[1] Michigan State Univ, Dept Obstet Gynecol & Reprod Biol, E Lansing, MI 48824 USA
[2] Michigan State Univ, Dept Epidemiol, E Lansing, MI 48824 USA
[3] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
[4] Univ Kansas, Ctr Reprod Med, Wichita, KS USA
[5] Stanford Univ, Med Ctr, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Stanford, CA 94305 USA
[6] Brigham & Womens Hosp, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Boston, MA 02115 USA
[7] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA
关键词
Sex ratio; ICSI; blastocyst-stage embryos transfers; male factor infertility; FETAL SEX; UNITED-STATES; BIRTH; ABNORMALITIES; FERTILITY; CHILDREN; WEIGHT; MEN;
D O I
10.1016/j.fertnstert.2008.08.107
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
Objective: To evaluate the effect of intracytoplasmic sperm injection (ICSI) and male factor infertility on the sex ratio in births from assisted reproductive technology. Design: Historic cohort study. Setting: Clinic-based data. Patient(s): The study population included 15,164 singleton live births in the Society for Assisted Reproductive Technology national database for 2005 from cycles using ejaculated sperm, categorized by the use of insemination or ICSI and the absence or presence of male factor infertility, and cleavage- versus blastocyst-stage embryo transfers (ETs). Intervention(s): None. Main Outcome Measure(S): The probability of a male infant with and without the use of ICSI and in the presence or absence of male factor infertility. Result(s): The sex ratio for all U.S. live births in 2005 was 52.5%, versus 48.9% for cleavage-stage and 51.6% for blastocyst-stage embryos. With blastocyst-stage embryos, the sex ratios were 49.60/', and 54.9% with and without ICSI and 52.6% and 50.0% with and without male factor infertility, respectively. With cleavage-stage embryos, the sex ratio was not significantly affected by ICSI or male factor infertility, singly or in combination. Conclusion(s): The use of ICSI, particularly with blastocyst-stage embryos, is associated with a decrease in the sex ratio of male infants. (Fertil Steril (R) 2009;92:1579-85. (C) 2009 by American Society for Reproductive Medicine.)
引用
收藏
页码:1579 / 1585
页数:7
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