Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera

被引：53

作者：

DiSimone, N ^{[1
]}

Ferrazzani, S ^{[1
]}

Castellani, R ^{[1
]}

DeCarolis, S ^{[1
]}

Mancuso, S ^{[1
]}

Caruso, A ^{[1
]}

机构：

[1] UNIV CATTOLICA SACRO CUORE, DEPT OBSTET & GYNECOL, I-00168 ROME, ITALY

来源：

HUMAN REPRODUCTION | 1997年 / 12卷 / 09期

关键词：

acetylsalicylic acid; antiphospholipid antibodies; HCG; heparin; trophoblast;

D O I：

10.1093/humrep/12.9.2061

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This study was conducted to determine whether drugs used for conventional treatments of pregnant women with antiphosholipid syndrome might be able to restore the gonadotrophin-releasing hormone (GnRH)-induced secretion of placental human chorionic gonadotrophin (HCG) in vitro, We tested this hypothesis using a modified enzyme-linked immunosorbent assay (ELISA) and an in-vitro placental culture system. Pharmacological dose of low molecular weight heparin (20 IU/ml) significantly (P < 0.02) reduced the antiphospholipid antibody (aPL) binding in the ELISA and was able to restore GnRH-induced HCG secretion (P < 0.05) in presence of aPL-containing sera, Low-dose aspirin (0.03 M) did not modify aPL binding in the ELISA, but partially restored HCG secretion (P < 0.05). These observations may help to explain the role of these treatments in antiphospholipid syndrome.

引用

页码：2061 / 2065

页数：5

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