Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation

被引：129

作者：

Yang, Liang ^{[2
]}

Nilsson, Martin ^{[1
]}

Gjermansen, Morten ^{[1
]}

Givskov, Michael ^{[1
]}

Tolker-Nielsen, Tim ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth Sci, Dept Int Hlth Immunol & Microbiol, Copenhagen, Denmark

[2] Tech Univ Denmark, Dept Syst Biol, DK-2800 Lyngby, Denmark

来源：

MOLECULAR MICROBIOLOGY | 2009年 / 74卷 / 06期

关键词：

QUINOLONE SIGNAL SYNTHESIS; FERRIPYOVERDINE RECEPTOR; MULTICELLULAR STRUCTURES; NUCLEOTIDE-SEQUENCE; EXTRACELLULAR DNA; IV PILI; IRON; EXPRESSION; GENE; CLONING;

D O I：

10.1111/j.1365-2958.2009.06934.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

P>Using flow chamber-grown Pseudomonas aeruginosa biofilms as model system, we show in the present study that formation of heterogeneous biofilms may occur through mechanisms that involve complex subpopulation interactions. One example of this phenomenon is expression of the iron-siderophore pyoverdine in one subpopulation being necessary for development of another subpopulation that does not itself express the pyoverdine synthesis genes. Another example is quorum sensing-controlled DNA release in one subpopulation being necessary for development of another subpopulation that does not itself express the quorum-sensing genes.

引用

页码：1380 / 1392

页数：13

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