Nitric oxide photorelease from ruthenium salen complexes in aqueous and organic solutions

被引：73

作者：

Bordini, J

Hughes, DL

Neto, JDD

da Cunha, CJ

机构：

[1] Univ Fed Parana, Ctr Politecn, Dept Quim, BR-81531990 Curitiba, Parana, Brazil

[2] John Innes Inst, Biol Chem Dept, Norwich NR4 7UH, Norfolk, England

来源：

INORGANIC CHEMISTRY | 2002年 / 41卷 / 21期

关键词：

D O I：

10.1021/ic011273d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The complexes [Ru(salen)(NO)Cl] and [Ru(salen)(NO)(H2O)](+) were shown to release the nitrosyl ligand as nitric oxide upon exposure to visible light in organic and aqueous solutions respectively, by means of W-visible, EPR, and FIR spectroscopies. The former was prepared by a new synthetic route and had its structure determined by single-crystal X-ray diffraction. A crystal of the dichloromethane solvate is orthorhombic, space group Fdd2 (No. 43) and formula C16H14ClN3O3Ru.CH2Cl2, with Z = 16 and cell parameters a = 25.489(4), b = 33.435(4), and c = 9.3716(g) Angstrom. The electronic absorption spectra of the complexes were calculated using the INDO/S method. The water-soluble complex is a potential drug for antitumoral phototreatment.

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页码：5410 / 5416

页数：7

相关论文

共 53 条

[1] NITRIC-OXIDE - SOME OLD AND NEW PERSPECTIVES [J].

AINSCOUGH, EW ;

BRODIE, AM .

JOURNAL OF CHEMICAL EDUCATION, 1995, 72 (08) :686-692

[2]

ALENCASTRO RB, 2001, INT J QUANTUM CHEM, V85, P529

[3] DINITROGEN COMPLEXES OF TUNGSTEN WITH BULKY PHOSPHINE CO-LIGANDS - PREPARATION AND CRYSTAL-STRUCTURES OF [(W(N2)2(PET2PH)3)2(MU-N2)], TRANS-[W(N2)2(PET2PH)4].C4H8O, AND "[W(ETA-6-C6H5PPRN2)(N-2)(PPRN2PH)2] AND THEIR REACTIONS TO GIVE HYDRAZINE OR AMMONIA [J].

ANDERSON, SN ;

RICHARDS, RL ;

HUGHES, DL .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1986, (02) :245-252

[4] AN INTERMEDIATE NEGLECT OF DIFFERENTIAL-OVERLAP MODEL FOR 2ND-ROW TRANSITION-METAL SPECIES [J].

ANDERSON, WP ;

CUNDARI, TR ;

ZERNER, MC .

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 1991, 39 (01) :31-45

[5] CALCULATED SPECTRA OF HYDRATED IONS OF THE 1ST TRANSITION-METAL SERIES [J].

ANDERSON, WP ;

EDWARDS, WD ;

ZERNER, MC .

INORGANIC CHEMISTRY, 1986, 25 (16) :2728-2732

[6] UTILITY OF THE SEMIEMPIRICAL INDO-1 METHOD FOR THE CALCULATION OF THE GEOMETRIES OF 2ND-ROW TRANSITION-METAL SPECIES [J].

ANDERSON, WP ;

CUNDARI, TR ;

DRAGO, RS ;

ZERNER, MC .

INORGANIC CHEMISTRY, 1990, 29 (01) :1-3

[7]

ARMAREGO WLF, 1997, PURFICATION LAB CHEM

[8] Synthesis and characterization of the mer-[RuCl3(NO)(dppb)] isomer.: X-ray structures of fac-[RuCl3(NO)(dppm)], cis-[RuCl2(dppm)2] and mer-[RuCl3(NO)(dppb)] [dppm=1,2-bis(diphenylphosphino)methane and dppb=1,4-bis(diphenylphosphino)butane] [J].

Batista, AA ;

Pereira, C ;

Wohnrath, K ;

Queiroz, SL ;

Santos, RHD ;

Gambardella, MTD .

POLYHEDRON, 1999, 18 (15) :2079-2083

[9] Nitrosyl ruthenium complexes with general formula [RuCl3,(NO)(P-P)] (P-P={PPh(2)(CH2)(n)PPh(2)},n=1-3 and {PPh(2)-CH=CH-PPh(2)}). X-ray structure of [RuCl3(NO){PPh(2)(CH2)(3)PPh(2)}] [J].

Batista, AA ;

Pereira, C ;

Queiroz, SL ;

deOliveira, LAA ;

Santos, RHD ;

Gambardella, MTD .

POLYHEDRON, 1997, 16 (06) :927-931

[10]

Bettache N, 1996, METHOD ENZYMOL, V268, P266

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