Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia

被引：61

作者：

Chapiro, Elise

Russell, Lisa

Radford-Weiss, Isabelle

Bastard, Christian

Lessard, Michel

Struski, Stephanie

Cave, Helene

Fert-Ferrer, Sandra

Barin, Carole

Maarek, Odile

Della-Valle, Veronique

Strefford, Jonathan C.

Berger, Roland

Harrison, Christine J.

Bernard, Olivier A.

Nguyen-Khac, Florence

机构：

[1] Grp Hosp Pitie Salpetriere, Serv Hematol Biol, AP HP, F-75013 Paris, France

[2] INSERM, Paris, France

[3] Univ Paris 06, Paris, France

[4] Univ Southampton, Leukaemia Res Cytogenet Grp, Canc Sci Div, Southampton, Hants, England

[5] Univ Paris 05, Paris, France

[6] Hop Necker Enfants Malad, Lab Cytogenet, AP HP, Paris, France

[7] Lab Genet Oncol, Rouen, France

[8] Hop Hautepierre, Hematol Lab, Strasbourg, France

[9] Hop Robert Debre, AP HP, Biochim Genet Lab, F-75019 Paris, France

[10] Genet Lab, Chambery, France

[11] Genet Lab, Tours, France

[12] Hop St Louis, AP HP, Hematol Lab, Paris, France

来源：

BLOOD | 2006年 / 108卷 / 10期

关键词：

D O I：

10.1182/blood-2006-03-010835

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Subtle variation in the expression or function of a small group of transcription factors can drive leukemogenesis. The CEBPA protein is known to regulate the balance between cell proliferation and differentiation during early hematopoietic development and myeloid differentiation. In human myeloid leukemia, CEBPA is frequently inactivated by mutation and indirect and post-translational mechanisms, in keeping with tumor suppressor properties. We report that CEBPA is activated by juxtaposition to the immunoglobulin gene enhancer upon its rearrangement with the immunoglobulin heavy-chain locus in precursor B-cell acute lymphoblastic leukemia harboring t(14;19)(q32;q13). Overexpression of apparently normal CEBPA RNA or protein was observed in 6 patients. These data indicate that CEBPA may exhibit oncogenic as well as tumor suppressor properties in human leukemogenesis.

引用

页码：3560 / 3563

页数：4

共 18 条

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