Fine-scale Identification of the Most Likely Source of a Human Plague Infection

被引:14
作者
Colman, Rebecca E. [1 ]
Vogler, Amy J. [1 ]
Lowell, Jennifer L. [2 ]
Gage, Kenneth L. [2 ]
Morway, Christina [2 ]
Reynolds, Pamela J. [3 ]
Ettestad, Paul [3 ]
Keim, Paul [1 ]
Kosoy, Michael Y. [2 ]
Wagner, David M. [1 ]
机构
[1] No Arizona Univ, Flagstaff, AZ 86011 USA
[2] Ctr Dis Control & Prevent, Ft Collins, CO USA
[3] New Mexico Dept Hlth, Santa Fe, NM USA
基金
美国国家卫生研究院;
关键词
YERSINIA-PESTIS; MUTATIONS; NUMBER; DNA;
D O I
10.3201/eid1510.090188
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We describe an analytic approach to provide fine-scale discrimination among multiple infection source hypotheses. This approach uses mutation-rate data for rapidly evolving multiple locus variable-number tandem repeat loci in probabilistic models to identify the most likely source. We illustrate the utility of this approach using data from a North American human plague investigation.
引用
收藏
页码:1623 / 1625
页数:3
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