Control of interleukin-2 gene transcription: A paradigm for inducible, tissue-specific gene expression

被引：19

作者：

Bunting, Karen ^{[1
]}

Wang, Jun ^{[1
]}

Shannon, M. Frances ^{[1
]}

机构：

[1] Australian Natl Univ, Div Mol Biosci, John Curtin Sch Med Res, Canberra, ACT, Australia

来源：

INTERLEUKINS | 2006年 / 74卷

关键词：

D O I：

10.1016/S0083-6729(06)74005-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-2 (IL-2) is a key cytokine that controls immune cell function, in particular the adaptive arm of the immune system, through its ability to control the clonal expansion and homeostasis of peripheral T cells. IL-2 is produced almost exclusively by T cells in response to antigenic stimulation and thus provides an excellent example of a cell-specific inducible gene. The mechanisms that control IL-2 gene transcription have been studied in detail for the past 20 years and our current understanding of the nature of the inducible and tissue-specific controls will be discussed. (c) 2006 Elsevier Inc.

引用

页码：105 / 145

页数：41

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