Tumour necrosis factor-alpha gene-238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy

被引：80

作者：

Nolan, D ^{[1
]}

Moore, C

Castley, A

Sayer, D

Mamotte, C

John, M

James, I

Mallal, S

机构：

[1] Royal Perth Hosp, Ctr Clin Immunol & Biomed Stat, Perth, WA, Australia

[2] Royal Perth Hosp, Dept Clin Immunol & Biochem Genet, Perth, WA, Australia

来源：

AIDS | 2003年 / 17卷 / 01期

关键词：

D O I：

10.1097/00002030-200301030-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of TNF polymorphisms on the time-to-onset of lipodystrophy was investigated in 191 Caucasian participants in the western Australian HIV cohort. Carriage of the TNF-alpha-238G/A polymorphism was found in 13.1% of the cohort, and was associated with an earlier onset of lipodystrophy. The presence of TNF-alpha-238G/A was associated with lipodystrophy progression in Cox proportional hazards regression analyses, without influencing the relative risk and significance of other predictive host and treatment-related variables.

引用

页码：121 / 123

页数：3

共 11 条

[1] Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance [J].

Bastard, JP ;

Caron, M ;

Vidal, H ;

Jan, V ;

Auclair, M ;

Vigouroux, C ;

Luboinski, J ;

Laville, M ;

Malachi, M ;

Girard, PM ;

Rozenbaum, W ;

Levan, P ;

Capeau, J .

LANCET, 2002, 359 (9311) :1026-1031

[2] Influence of TNFα gene polymorphisms on TNFα production and disease [J].

Hajeer, AH ;

Hutchinson, IV .

HUMAN IMMUNOLOGY, 2001, 62 (11) :1191-1199

[3]

John M, 2001, ANTIVIR THER, V6, P9

[4]

LLORETA J, 2001, 1 IAS C HIV PATH TRE

[5]

MAHER B, 2000, 13 INT AIDS C DURB

[6]

MALLAL S, 2000, 13 INT AIDS C DURB

[7] Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection [J].

Mallal, SA ;

John, M ;

Moore, CB ;

James, IR ;

McKinnon, EJ .

AIDS, 2000, 14 (10) :1309-1316

[8] Synergistic antiadipogenic effects of HIV type 1 protease inhibitors with tumor necrosis factor α:: Suppression of extracellular insulin action mediated by extracellular matrix-degrading proteases [J].

Mondal, D ;

Larussa, VF ;

Agrawal, KC .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2001, 17 (17) :1569-1584

[9]

Nolan D, 2001, J HIV Ther, V6, P32

[10] TNFα induces and insulin inhibits caspase 3-dependent adipocyte apoptosis [J].

Qian, H ;

Hausman, DB ;

Compton, MM ;

Martin, RJ ;

Della-Fera, MA ;

Hartzell, DL ;

Baile, CA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 284 (05) :1176-1183

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