A closer look at the cholesterol sensor

被引：40

作者：

Gimpl, G ^{[1
]}

Burger, K ^{[1
]}

Fahrenholz, F ^{[1
]}

机构：

[1] Univ Mainz, Inst Biochem, D-55099 Mainz, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 12期

关键词：

D O I：

10.1016/S0968-0004(02)02224-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transport of the sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP)-SREBP complex from the endoplasmic reticulum (ER) to the Golgi is the central event mediating the cholesterol-feedback process in mammalian cells. A conformational change in SCAP is a crucial step; when cholesterol levels are high, the conformation of SCAP enables the SCAP-SREBP complex to associate with an insulin-induced gene (INSIG) retention protein in the ER. By contrast, when cholesterol levels are low, SCAP switches to a conformation that enables the dissociation of the retention protein and the association of SCAP-SREBP with COP II vesicles.

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收藏

页码：596 / 599

页数：4

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