Phospholipid transfer protein in lipid metabolism

被引：27

作者：

Huuskonen, J ^{[1
]}

Ehnholm, C ^{[1
]}

机构：

[1] Natl Publ Hlth Inst, Dept Biochem, SF-00300 Helsinki, Finland

来源：

CURRENT OPINION IN LIPIDOLOGY | 2000年 / 11卷 / 03期

关键词：

D O I：

10.1097/00041433-200006000-00009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipid transfer protein (PLTP) is one of the main modulators of plasma HDL size and composition. The publications discussed in the present review have substantially increased our knowledge on the physiological importance of PLTP-mediated phospholipid transfer, especially between triglyceride-rich lipoproteins and HDL. Furthermore, novel data have provided clues about the transfer mechanism, and evidence for the direct involvement of PLTP in atheroprotection has recently been presented. The development of assays for PLTP mass determination has offered new tools for the elucidation of the physiological role of PLTP. Curr Opin Lipidol 11:285-289. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：285 / 289

页数：5

共 40 条

[1] Transgenic mice expressing human phospholipid transfer protein have increased HDL non-HDL cholesterol ratio [J].

Albers, JJ ;

Tu, AY ;

Paigen, B ;

Chen, H ;

Cheung, MC ;

Marcovina, SM .

INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH, 1996, 26 (04) :262-267

[2]

Albers JJ, 1999, J LIPID RES, V40, P295

[3] Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution [J].

Beamer, LJ ;

Carroll, SF ;

Eisenberg, D .

SCIENCE, 1997, 276 (5320) :1861-1864

[4]

Capodici C, 1996, J IMMUNOL, V156, P4789

[5] EARLY INCORPORATION OF CELL-DERIVED CHOLESTEROL INTO PRE-BETA-MIGRATING HIGH-DENSITY LIPOPROTEIN [J].

CASTRO, GR ;

FIELDING, CJ .

BIOCHEMISTRY, 1988, 27 (01) :25-29

[6] Plasma phospholipid mass transfer rate: Relationship to plasma phospholipid and cholesteryl ester transfer activities and lipid parameters [J].

Cheung, MC ;

Wolfbauer, G ;

Albers, JJ .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1303 (02) :103-110

[7]

DAY JR, 1994, J BIOL CHEM, V269, P9388

[8] Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering α-tocopherol to endothelial cells [J].

Desrumaux, C ;

Deckert, V ;

Athias, A ;

Masson, D ;

Lizard, G ;

Palleau, V ;

Gambert, P ;

Lagrost, L .

FASEB JOURNAL, 1999, 13 (08) :883-892

[9] Mass concentration of plasma phospholipid transfer protein in normolipidemic, type IIa hyperlipidemic, type IIb hyperlipidemic, and non-insulin-dependent diabetic subjects as measured by a specific ELISA [J].

Desrumaux, C ;

Athias, A ;

Bessède, G ;

Vergès, B ;

Farnier, M ;

Perségol, L ;

Gambert, P ;

Lagrost, L .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (02) :266-275

[10]

Ehnholm S, 1998, J LIPID RES, V39, P1248

← 1 2 3 4 →