Surface Modification Changes the Degradation Process and Degradation Product Pattern of Polylactide

被引：73

作者：

Hoglund, Anders ^{[1
]}

Hakkarainen, Minna ^{[1
]}

Edlund, Ulrica ^{[1
]}

Albertsson, Ann-Christine ^{[1
]}

机构：

[1] Royal Inst Technol KTH, Dept Fibre & Polymer Technol, Sch Chem Sci & Engn, S-10044 Stockholm, Sweden

来源：

LANGMUIR | 2010年 / 26卷 / 01期

关键词：

STRUCTURE-PROPERTY RELATIONSHIPS; RING-OPENING POLYMERIZATION; HYDROLYTIC DEGRADATION; EPSILON-CAPROLACTONE; MASS-SPECTROMETRY; ALIPHATIC POLYESTERS; POLY(DL-LACTIC ACID); ESI-MS; COPOLYMERS; FUNCTIONALIZATION;

D O I：

10.1021/la902166j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of surface modification on the degradation process and degradation product patterns of degradable polymers is still a basically unexplored area even though it significant effect can be expected. Polylactide (PLA) and PLA grafted with acrylic acid (PLA-AA) were, thus, subjected to hydrolytic degradation, and water-soluble degradation products were determined by electrospray ionization-mass spectrometry (ESI-MS) after different time periods. Low molar mass Compounds migrated from surface-grafted PLA already during the first 7 days at 37 degrees C, while it Look 133 days in the case of nongrafted PLA before any low molar mass compounds were detected in the aging water. In addition, the degradation product pattern of surface-grafted PLA showed significant variation as a function of hydrolysis time with the evolution of short and long AA-grafted lactic acid oligomers as well as plain lactic acid oligomers after different time periods, The degradation up to 13 lactic acid units. Surface grafting, thus, changed the degradation product patterns and accelerated the formation of water-soluble degradation products.

引用

页码：378 / 383

页数：6

共 23 条

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