Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus

被引：106

作者：

Brunetti, L ^{[1
]}

Recinella, L ^{[1
]}

Orlando, G ^{[1
]}

Michelotto, B ^{[1
]}

Di Nisio, C ^{[1
]}

Vacca, M ^{[1
]}

机构：

[1] Univ G DAnnunzio, Dept Drug Sci, I-66013 Chieti, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 454卷 / 2-3期

关键词：

amylin; ghrelin; hypothalamus; dopamine; norepinephrine; 5-HT; (5-hydroxytryptamine; serotonin);

D O I：

10.1016/S0014-2999(02)02552-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ghrelin and amylin are gut-derived hormones that stimulate and inhibit food intake, respectively. Feeding is modulated by aminergic neurotransmitters in the hypothalamus. We have evaluated the effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release from rat hypothalamic synaptosomes. We found that ghrelin did not modify doparnine or norepinephrine release, but inhibited serotonin release. On the other hand, amylin inhibited dopamine release, without affecting norepinephrine or serotonin. We conclude that the appetite-stimulating activity of ghrelin could be mediated by inhibited serotonin release, while the anorectic effects of amylin could involve inhibited release of dopamine in the hypothalamus. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：189 / 192

页数：4

共 25 条

[1] Differential permeability of the blood-brain barrier to two pancreatic peptides: Insulin and amylin [J].

Banks, WA ;

Kastin, AJ .

PEPTIDES, 1998, 19 (05) :883-889

[2] PERMEABILITY OF THE BLOOD-BRAIN-BARRIER TO AMYLIN [J].

BANKS, WA ;

KASTIN, AJ ;

MANESS, LM ;

HUANG, WT ;

JASPAN, JB .

LIFE SCIENCES, 1995, 57 (22) :1993-2001

[3] Cocaine- and amphetamine-regulated transcript peptide-(55-102) and thyrotropin releasing hormone inhibit hypothalamic dopamine release [J].

Brunetti, L ;

Orlando, G ;

Michelotto, B ;

Recinella, L ;

Vacca, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 409 (02) :103-107

[4] Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings [J].

Brunetti, L ;

Michelotto, B ;

Orlando, G ;

Vacca, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 372 (03) :237-240

[5] ANOREXIA FOLLOWING THE SYSTEMIC INJECTION OF AMYLIN [J].

CHANCE, WT ;

BALASUBRAMANIAM, A ;

STALLION, A ;

FISCHER, JE .

BRAIN RESEARCH, 1993, 607 (1-2) :185-188

[6] Distribution of amylin-immunoreactive neurons in the monkey hypothalamus and their relationships with the histaminergic system [J].

D'Este, L ;

Wimalawansa, SJ ;

Renda, TG .

ARCHIVES OF HISTOLOGY AND CYTOLOGY, 2001, 64 (03) :295-303

[7] Dexfenfluramine - An updated review of its therapeutic use in the management of obesity [J].

Davis, R ;

Faulds, D .

DRUGS, 1996, 52 (05) :696-724

[8] EVIDENCE THAT NEUROPEPTIDE-Y AND DOPAMINE IN THE PERIFORNICAL HYPOTHALAMUS INTERACT ANTAGONISTICALLY IN THE CONTROL OF FOOD-INTAKE [J].

GILLARD, ER ;

DANG, DQ ;

STANLEY, BG .

BRAIN RESEARCH, 1993, 628 (1-2) :128-136

[9] Interacting appetite-regulating pathways in the hypothalamic regulation of body weight [J].

Kalra, SP ;

Dube, MG ;

Pu, SY ;

Xu, B ;

Horvath, TL ;

Kalra, PS .

ENDOCRINE REVIEWS, 1999, 20 (01) :68-100

[10] Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].

Kojima, M ;

Hosoda, H ;

Date, Y ;

Nakazato, M ;

Matsuo, H ;

Kangawa, K .

NATURE, 1999, 402 (6762) :656-660

← 1 2 3 →