Microbial aldolases and transketolases: New biocatalytic approaches to simple and complex sugars

被引:71
作者
Takayama, S
McGarvey, GJ
Wong, CH
机构
[1] Department of Chemistry, Scripps Research Institute, San Diego, CA 92037
关键词
recombinant enzymes; carbohydrate recognition; enzyme inhibitors; multienzyme synthesis; stereoselective synthesis;
D O I
10.1146/annurev.micro.51.1.285
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Enzymes have become exceedingly valuable tools in organic synthesis as the reactions they catalyze generally proceed under mild conditions and in high stereo- and regioselectivity. Advances in microbiology and genetic engineering have greatly increased the availability of various enzymes. One of the most useful applications of enzyme-catalyzed chemical transformations is in the synthesis of water-soluble, polyfunctional organic molecules such as carbohydrates. As the pivotal roles that carbohydrates play in biological processes become more evident, access to these compounds becomes increasingly important. This review gives a brief overview of the use of aldolases and transketolases in the synthesis of sugars, sugar analogs, and related compounds.
引用
收藏
页码:285 / 310
页数:26
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