Apoptosis - Gone but not forgotten

被引：78

作者：

Green, DR ^{[1
]}

Beere, HM ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA

来源：

NATURE | 2000年 / 405卷 / 6782期

关键词：

D O I：

10.1038/35011175

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cells that have died by apoptosis are taken up by phagocytic cells, and a receptor on the phagocytes that allows them to recognize the apoptotic cells has now been identified. Binding of ligand to the receptor triggers the release of anti-inflammatory cytokines, ensuring that the apoptotic cell has a lasting effect on phagocyte behaviour.

引用

页码：28 / 29

页数：2

共 8 条

[1] Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
Albert, ML
Pearce, SFA
Francisco, LM
Sauter, B
Roy, P
Silverstein, RL
Bhardwaj, N
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (07) : 1359 - 1368
[2] FADOK VA, 1992, J IMMUNOL, V149, P4029
[3] A receptor for phosphatidylserine-specific clearance of apoptotic cells
Fadok, VA
Bratton, DL
Rose, DM
Pearson, A
Ezekewitz, RAB
Henson, PM
[J]. NATURE, 2000, 405 (6782) : 85 - 90
[4] Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
Fadok, VA
Bratton, DL
Konowal, A
Freed, PW
Westcott, JY
Henson, PM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (04) : 890 - 898
[5] Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S
Lolkema, M
Matzinger, P
[J]. NATURE MEDICINE, 1999, 5 (11) : 1249 - 1255
[6] Apoptosis: The importance of being eaten
Ren, Y
Savill, J
[J]. CELL DEATH AND DIFFERENTIATION, 1998, 5 (07) : 563 - 568
[7] Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
Sauter, B
Albert, ML
Francisco, L
Larsson, M
Somersan, S
Bhardwaj, N
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (03) : 423 - 433
[8] The induction of tolerance by dendritic cells that have captured apoptotic cells
Steinman, RM
Turley, S
Mellman, I
Inaba, K
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (03) : 411 - 416

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