Bioactivity of beer and its influence on human metabolism

被引:48
作者
Gorinstein, Shela
Caspi, Abraham
Libman, Imanuel
Leontowicz, Hanna
Leontowicz, Maria
Tashma, Zev
Katrich, Elena
Jastrzebski, Zenon
Trakhtenberg, Simon
机构
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel
[2] Kaplan Univ, Med Ctr, Inst Cardiol, Rehovot, Israel
[3] Agr Univ Warsaw, Fac Vet Med, Dept Physiol Sci, Warsaw, Poland
[4] Inst Publ Hlth, Dept Pharmacol, Warsaw, Poland
关键词
beer; bioactivity; plasma albumin; lipids;
D O I
10.1080/09637480601108661
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Extracted total phenols, flavanols and flavonoids were measured in beer samples and their quality as antioxidants was measured by two modified antioxidant methods: the 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS (center dot+)) and the beta-carotene-linoleate model system (beta-carotene). It was found that the antioxidant potential of beer was well correlated with flavanols and flavonoids and was slightly lower with total polyphenols (R 2 values from 0.8203 to 0.9393). Forty-two male non drinkers, hypercholesterolaemic volunteers ages 43-71 after coronary bypass surgery, were randomly divided into experimental (EG) and control (CG) groups, each of 21 participants. The antiatherosclerotic diet of the EG group was supplemented for 30 consecutive days with 330 ml beer per day. Could short-term beer consumption affect not only the risk factors of coronary atherosclerosis, but also the markers of this process: plasma albumin and its antioxidant activity? For this goal, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, plasma albumin and fibrinogen, and the antioxidant activity were determined. After the trial a significant improvement in the plasma lipid levels, and an increase in the plasma antioxidant and anticoagulant activities in patients of the EG group was registered. A parallel increase in the plasma albumin concentration and its antioxidant activity was observed. In conclusion, short-term beer consumption on the basis of the bioactivity of the beverage positively affects plasma lipid levels, plasma antioxidant and anticoagulant activities. The increase in the plasma albumin concentration and its antioxidant activity could be the markers of atherosclerosis status.
引用
收藏
页码:94 / 107
页数:14
相关论文
共 36 条
[1]   Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines [J].
Arnous, A ;
Makris, DP ;
Kefalas, P .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (12) :5736-5742
[2]   Coronary heart disease risk reduction in a predominantly beer-drinking population [J].
Brenner, H ;
Rothenbacher, D ;
Bode, G ;
März, W ;
Hoffmeister, A ;
Koenig, W .
EPIDEMIOLOGY, 2001, 12 (04) :390-395
[3]   Alcohol drinking and cardiac risk [J].
Buemann, B ;
Dyerberg, J ;
Astrup, A .
NUTRITION RESEARCH REVIEWS, 2002, 15 (01) :91-121
[4]  
Cepicka J, 2002, CHEM LISTY, V96, P90
[5]   EFFECT OF ALCOHOL ON GLUCOSE, INSULIN, FREE FATTY-ACID AND TRIACYLGLYCEROL RESPONSES TO A LIGHT MEAL IN NON-INSULIN-DEPENDENT DIABETIC SUBJECTS [J].
CHRISTIANSEN, C ;
THOMSEN, C ;
RASMUSSEN, O ;
HAUERSLEV, C ;
BALLE, M ;
HANSEN, C ;
HERMANSEN, K .
BRITISH JOURNAL OF NUTRITION, 1994, 71 (03) :449-454
[6]   Beer increases plasma antioxidant capacity in humans [J].
Ghiselli, A ;
Natella, F ;
Guidi, A ;
Montanari, L ;
Fantozzi, P ;
Scaccini, C .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2000, 11 (02) :76-80
[7]   Plasma circulating fibrinogen stability and moderate beer consumption [J].
Gorinstein, S ;
Caspi, A ;
Zemser, M ;
Libman, I ;
Goshev, I ;
Trakhtenberg, S .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2003, 14 (12) :710-716
[8]   Moderate beer consumption and positive biochemical changes in patients with coronary atherosclerosis [J].
Gorinstein, S ;
Zemser, M ;
Berliner, M ;
Goldstein, R ;
Libman, I ;
Trakhtenberg, S ;
Caspi, A .
JOURNAL OF INTERNAL MEDICINE, 1997, 242 (03) :219-224
[9]   Effects of the frequency of alcohol intake on risk factors for coronary heart disease [J].
Hashimoto, Y ;
Futamura, A ;
Nakarai, H ;
Nakahara, K .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2001, 17 (04) :307-312
[10]  
Hendriks HFJ, 2001, ALCOHOL CLIN EXP RES, V25, P563