A systematic review of human antioxidant genes

被引：38

作者：

Gelain, Daniel P. ^{[1
]}

Dalmolin, Rodrigo J. S. ^{[1
]}

Belau, Vanessa L. ^{[1
]}

Moreira, Jose C. F. ^{[1
]}

Klamt, Fabio ^{[1
]}

Castro, Mauro A. A. ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Unidade Bioinformat, Ctr Estudos Estresse Oxidat, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Luterana Brasil, BR-94170240 Gravatai, Brazil

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Antioxidant; Oxidative Stress; Gene Network; Reactive Oxygen Species; Peroxidases; Superoxide Dismutases; Thiol-redox; Systems Biology; Review;

D O I：

10.2741/3541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The balance between production and clearance of reactive species is essential for cell survival. Antioxidant cellular systems evolved to maintain a redox homeostasis under different physiological and pathological conditions. Therefore, many authors aim at better understanding the mechanisms and functions of cellular antioxidant components and their relationships between each other and with more general cell functions. Nonetheless, the definition of an "antioxidant system" is a wide and sometimes relative concept, and there is no consensus regarding the necessary requisites for classifying a cell functional component into such category. Here, we suggest a list of human antioxidant genes comprehending all gene products fulfilling specific inclusion criteria, such as antioxidant enzymatic function, participation in redox reactions and other molecular interactions directly related to antioxidant activity. The criteria are discussed and the gene-protein-substrate associations between the components of the list are presented. In addition, at http://www.ufrgs.br/icbs/hag we provide a network-based model of human antioxidant genes, which can be used as reference tool to access several database resources (e.g., RefSeq, Ensembl, HGNC and the NCBI Entrez database).

引用

页码：4457 / 4463

页数：7

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