Tumor suppressors and oncogenes in cellular senescence

被引：307

作者：

Bringold, F ^{[1
]}

Serrano, M ^{[1
]}

机构：

[1] Natl Biotechnol Ctr, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

EXPERIMENTAL GERONTOLOGY | 2000年 / 35卷 / 03期

关键词：

senescence; cell-cycle; Ras; Myc;

D O I：

10.1016/S0531-5565(00)00083-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cyclin-dependent kinase inhibitors p16(INK4a), p21(Cip1), and p27(Kip1) are regarded as key effecters of cellular senescence. In this review, we describe three senescence-inducing pathways involving these inhibitors, namely, the p16(INK4a)/Rb pathway, the p19(ARF)/p53/p21(Cip1) pathway, and the PTEN/p27(Kip1) pathway. We emphasize the participation of tumor suppressors and oncogenes in the regulation of these senescence-inducing pathways. Finally, we discuss the impact of the Ras and Myc oncogenes on the above-mentioned pathways. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：317 / 329

页数：13

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