Sepsis: the dark side of histones

被引：70

作者：

Chaput, Catherine ^{[1
]}

Zychlinsky, Arturo ^{[1
]}

机构：

[1] Max Planck Inst Infect Biol, Dept Cellular Microbiol, Berlin, Germany

来源：

NATURE MEDICINE | 2009年 / 15卷 / 11期

关键词：

D O I：

10.1038/nm1109-1245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318-1321), which are toxic during severe sepsis.

引用

页码：1245 / 1246

页数：2

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