Lipid rafts, detergent-resistant membranes, and raft targeting signals

被引：357

作者：

Brown, Deborah A. ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA

来源：

PHYSIOLOGY | 2006年 / 21卷

关键词：

D O I：

10.1152/physiol.00032.2006

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Lipid rafts are liquid-ordered (I.) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating I-o-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.

引用

页码：430 / 439

页数：10

共 121 条

[1] On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: Physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes
Ahmed, SN
Brown, DA
London, E
[J]. BIOCHEMISTRY, 1997, 36 (36) : 10944 - 10953
[2] Alberts B., 2002, Molecular Biology of The Cell, V4th
[3] Membrane binding of peptides containing both basic and aromatic residues.: Experimental studies with peptides corresponding to the scaffolding region of caveolin and the effector region of MARCKS
Arbuzova, A
Wang, LB
Wang, JY
Hangyás-Mihályné, G
Murray, D
Honig, B
McLaughlin, S
[J]. BIOCHEMISTRY, 2000, 39 (33) : 10330 - 10339
[4] Essential role of CD8 palmitoylation in CD8 coreceptor function
Arcaro, A
Grégoire, C
Boucheron, N
Stotz, S
Palmer, E
Malissen, B
Luescher, IF
[J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (04) : 2068 - 2076
[5] CD8β endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56lck complexes
Arcaro, A
Grégoire, C
Bakker, TR
Baldi, L
Jordan, M
Goffin, L
Boucheron, N
Wurm, F
van der Merwe, PA
Malissen, B
Luescher, IF
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (10) : 1485 - 1495
[6] Cyclic β-1,2-glucan is a brucella virulence factor required for intracellular survival
Arellano-Reynoso, B
Lapaque, N
Salcedo, S
Briones, G
Ciocchini, AE
Ugalde, R
Moreno, E
Moriyón, I
Gorvel, JP
[J]. NATURE IMMUNOLOGY, 2005, 6 (06) : 618 - 625
[7] Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues
Arni, S
Keilbaugh, SA
Ostermeyer, AG
Brown, DA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) : 28478 - 28485
[8] Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling
Arron, JR
Pewzner-Jung, Y
Walsh, MC
Kobayashi, T
Choi, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (07) : 923 - 934
[9] CD4 raft association and signaling regulate molecular clustering at the immunological synapse site
Balamuth, F
Brogdon, JL
Bottomly, K
[J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (10) : 5887 - 5892
[10] Raft localisation of FcγRIIa and efficient signaling are dependent on palmitoylation of cysteine 208
Barnes, NC
Powell, MS
Trist, HM
Gavin, AL
Wines, BD
Hogarth, PM
[J]. IMMUNOLOGY LETTERS, 2006, 104 (1-2) : 118 - 123

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