New and Current Clinical Imaging Techniques to Study Chronic Obstructive Pulmonary Disease

被引:103
作者
Coxson, Harvey O. [1 ,2 ,4 ]
Mayo, John [2 ,3 ,4 ]
Lam, Stephen [3 ,5 ]
Santyr, Giles [6 ,7 ,8 ]
Parraga, Grace [6 ,7 ,8 ]
Sin, Don D. [1 ,2 ,3 ]
机构
[1] St Pauls Hosp, Providence Heart & Lung Inst, Vancouver, BC V6Z 1Y6, Canada
[2] St Pauls Hosp, James Hogg iCAPTURE Ctr, Vancouver, BC V6Z 1Y6, Canada
[3] Univ British Columbia, Dept Med, Vancouver, BC, Canada
[4] Univ British Columbia, Dept Radiol, Vancouver, BC, Canada
[5] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada
[6] Robarts Res Inst, Imaging Res Labs, London, ON N6A 5C1, Canada
[7] Univ Western Ontario, Dept Med Biophys, London, ON, Canada
[8] Univ Western Ontario, Dept Med Imaging, London, ON, Canada
关键词
chronic obstructive pulmonary disease; imaging; phenotype; OPTICAL COHERENCE TOMOGRAPHY; APPARENT DIFFUSION-COEFFICIENTS; AIRWAY WALL THICKNESS; OXYGEN-ENHANCED MRI; COMPUTED-TOMOGRAPHY; MAGNETIC-RESONANCE; LUNG DENSITY; ANALYSIS ALGORITHM; DYNAMIC MRI; EMPHYSEMA;
D O I
10.1164/rccm.200901-0159PP
中图分类号
R4 [临床医学];
学科分类号
100218 [急诊医学];
摘要
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by both small airway and parenchymal abnormalities. There is increasing evidence to suggest that these two morphologic phenotypes, although related, may have different clinical presentations, prognosis, and therapeutic responses to medications. With the advent of novel imaging modalities, it is now possible to evaluate these two morphologic phenotypes in large clinical studies using noninvasive or minimally invasive methods such as computed tomography (CT), magnetic resonance imaging (MRI), and optical coherence tomography (OCT). In this article, we provide an overview of these imaging modalities in the context of COPD and discuss their strengths as well as their limitations for providing quantitative COPD phenotypes.
引用
收藏
页码:588 / 597
页数:10
相关论文
共 80 条
[1]
Aldrich JE, 2006, CAN ASSOC RADIOL J, V57, P79
[2]
Assessment of Regional Progression of Pulmonary Emphysema With CT Densitometry [J].
Bakker, M. Els ;
Putter, Hein ;
Stolk, Jan ;
Shaker, Saher B. ;
Piitulainen, Eeva ;
Russi, Erich W. ;
Stoel, Berend C. .
CHEST, 2008, 134 (05) :931-937
[3]
Emphysema: Effect of reconstruction algorithm on CT imaging measures [J].
Boedeker, KL ;
McNitt-Gray, MF ;
Rogers, SR ;
Truong, DA ;
Brown, MS ;
Gjertson, DW ;
Goldin, JG .
RADIOLOGY, 2004, 232 (01) :295-301
[4]
Boschetto P, 2003, EUR RESPIR J, V21, P450, DOI 10.1183/09031936.03.00048703
[5]
Current concepts - Computed tomography - An increasing source of radiation exposure [J].
Brenner, David J. ;
Hall, Eric J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (22) :2277-2284
[6]
Transpleural ventilation of explanted human lungs [J].
Choong, Cliff K. ;
Macklem, Peter T. ;
Pierce, John A. ;
Lefrak, Stephen S. ;
Woods, Jason C. ;
Conradi, Mark S. ;
Yablonskiy, Dimitry A. ;
Hogg, James C. ;
Chino, Kimiaki ;
Cooper, Joel D. .
THORAX, 2007, 62 (07) :623-630
[7]
Diaphragm and chest wall: Assessment of the inspiratory pump with MR imaging - Preliminary observations [J].
Cluzel, P ;
Similowski, T ;
Chartrand-Lefebvre, C ;
Zelter, M ;
Derenne, JP ;
Grenier, PA .
RADIOLOGY, 2000, 215 (02) :574-583
[8]
Airway wall thickness assessed using computed tomography and optical coherence tomography [J].
Coxson, Harvey O. ;
Quiney, Brendan ;
Sin, Don D. ;
Xing, Li ;
McWilliams, Annette M. ;
Mayo, John R. ;
Lam, Stephen .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (11) :1201-1206
[9]
Coxson Harvey O, 2008, Proc Am Thorac Soc, V5, P874, DOI 10.1513/pats.200810-118QC
[10]
A quantification of the lung surface area in emphysema using computed tomography [J].
Coxson, HO ;
Rogers, RM ;
Whittall, KP ;
D'Yachkova, Y ;
Paré, PD ;
Sciurba, FC ;
Hogg, JC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (03) :851-856