Synthesis of pyranose glycals via tungsten and molybdenum pentacarbonyl-induced alkynol cyclizations

被引：46

作者：

McDonald, FE

Zhu, HYH

机构：

[1] Department of Chemistry, Northwestern University, Evanston, IL 60208-3113

来源：

TETRAHEDRON | 1997年 / 53卷 / 32期

关键词：

D O I：

10.1016/S0040-4020(97)00366-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tungsten pentacarbonyl-induced cyclization of an acyclic alkynol substrate bearing protected oxygen and nitrogen functional groups provides the cyclic tungsten oxacarbene, which is readily converted into a pyranose glycal structurally related to the carbohydrate moieties of the pluramycin and vancomycin families of antitumor antibiotics. In addition a molybdenum-catalyzed cycloisomerization procedure provides an alternative route to this pyranose glycal. (C) 1997 Elsevier Science Ltd.

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页码：11061 / 11068

页数：8

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