Treatment of Osteosarcoma. The Scandinavian Sarcoma Group Experience

被引:20
作者
Bruland, Oyvind S. [1 ]
Bauer, Henrik [1 ]
Alvegaard, Thor [1 ]
Smeland, Sigbjorn [1 ]
机构
[1] Univ Oslo, Norwegian Radium Hosp, N-0310 Oslo, Norway
来源
PEDIATRIC AND ADOLESCENT OSTEOSARCOMA | 2009年 / 152卷
关键词
HIGH-DOSE METHOTREXATE; PREOPERATIVE CHEMOTHERAPY; EXTREMITY;
D O I
10.1007/978-1-4419-0284-9_16
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Results from four consecutive trials, conducted from 1982 by members of the Scandinavian Sarcoma Group, are reviewed. A total of 330 classical osteosarcoma patients were enrolled. In all trials chemotherapy was based on the three active drugs, methotrexate, doxorubicin and cisplatinum and for the latter trials also ifosfamide. Post-operative chemotherapy was stratified by histological response to up-front treatment.
引用
收藏
页码:309 / +
页数:3
相关论文
共 16 条
[1]
Alvegård TA, 2004, ACTA ORTHOP SCAND, V75, P1
[2]
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy [J].
Bruland, OS ;
Pihl, A .
EUROPEAN JOURNAL OF CANCER, 1997, 33 (11) :1725-1731
[3]
Hematogenous micrometastases in osteosarcoma patients [J].
Bruland, OS ;
Hoifodt, H ;
Sæter, G ;
Smeland, S ;
Fodstad, O .
CLINICAL CANCER RESEARCH, 2005, 11 (13) :4666-4673
[4]
CADE S, 1955, J R Coll Surg Edinb, V1, P79
[5]
OSTEOSARCOMA OF BONE AND ITS IMPORTANT RECOGNIZABLE VARIETIES [J].
DAHLIN, DC ;
UNNI, KK .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1977, 1 (01) :61-72
[6]
DELPREVER AB, 2005, ASCO M, V23, P9002
[7]
Neoadjuvant chemotherapy with high-dose ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity:: A joint study by the Italian and Scandinavian Sarcoma Groups [J].
Ferrari, S ;
Smeland, S ;
Mercuri, M ;
Bertoni, F ;
Longhi, A ;
Ruggieri, P ;
Alvegard, TA ;
Picci, P ;
Capanna, R ;
Bernini, G ;
Müller, C ;
Tienghi, A ;
Wiebe, T ;
Comandone, A ;
Böhling, T ;
Del Prever, AB ;
Brosjö, O ;
Bacci, G ;
Sæter, G .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (34) :8845-8852
[8]
Huvos A, 1991, Bone Tumors: Diagnosis. Treatment and Prognosis, V2nd, P85
[9]
Malawar M., 2005, Cancer Prinicples and Practice of Oncology, P1638
[10]
ROSEN G, 1979, CANCER-AM CANCER SOC, V43, P2163, DOI 10.1002/1097-0142(197906)43:6<2163::AID-CNCR2820430602>3.0.CO