Does activation-induced deaminase initiate antibody diversification by DNA deamination?

被引：4

作者：

Stavnezer, J ^{[1
]}

Bradley, SP ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Program Immunol & Virol, Worcester, MA 01655 USA

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 11期

关键词：

D O I：

10.1016/S0168-9525(02)02799-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Activation-induced deaminase (AID) is expressed only in germinal center B cells. There, it is required for somatic hypermutation, gene conversion and class switch recombination of antibody variable region segments, three processes that diversify antibodies during immune responses. Although AID has homology to RNA-editing enzymes, three recent reports suggest it could initiate the diversification processes by deaminating cyticline residues within the antibody genes themselves.

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页码：541 / 543

页数：3

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