Competition between multiple totally asymmetric simple exclusion processes for a finite pool of resources

被引:57
作者
Cook, L. Jonathan [1 ]
Zia, R. K. P. [1 ]
Schmittmann, B. [1 ]
机构
[1] Virginia Tech, Dept Phys, Blacksburg, VA 24061 USA
来源
PHYSICAL REVIEW E | 2009年 / 80卷 / 03期
基金
美国国家科学基金会;
关键词
LATTICE GASES; SPECTRAL GAP; DIFFUSION; MODEL; DYNAMICS; KINETICS; SYSTEM; CHAIN;
D O I
10.1103/PhysRevE.80.031142
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
Using Monte Carlo simulations and a domain-wall theory, we discuss the effect of coupling several totally asymmetric simple exclusion processes (TASEPs) to a finite reservoir of particles. This simple model mimics directed biological transport processes in the presence of finite resources such as protein synthesis limited by a finite pool of ribosomes. If all TASEPs have equal length, we find behavior which is analogous to a single TASEP coupled to a finite pool. For the more generic case of chains with different lengths, several unanticipated regimes emerge. A generalized domain-wall theory captures our findings in good agreement with simulation results.
引用
收藏
页数:12
相关论文
共 49 条
[1]   Power spectra of the total occupancy in the totally asymmetric simple exclusion process [J].
Adams, D. A. ;
Zia, R. K. P. ;
Schmittmann, B. .
PHYSICAL REVIEW LETTERS, 2007, 99 (02)
[2]   Far-from-equilibrium transport with constrained resources [J].
Adams, D. A. ;
Schmittmann, B. ;
Zia, R. K. P. .
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, 2008,
[3]  
BELITZKY V, 2002, ELECT J PROBAB, V7
[4]   Clustered bottlenecks in mRNA translation and protein synthesis [J].
Chou, T ;
Lakatos, G .
PHYSICAL REVIEW LETTERS, 2004, 93 (19) :198101-1
[5]   Ribosome recycling, diffusion, and mRNA loop formation in translational regulation [J].
Chou, T .
BIOPHYSICAL JOURNAL, 2003, 85 (02) :755-773
[6]  
Chowdhury D, 1999, CURR SCI INDIA, V77, P411
[7]  
Committee on CMMP 2010 Solid State Sciences Committee National Research Council, 2007, COND MATT MAT PHYS S
[8]  
COOK L, UNPUB
[9]   Feedback and fluctuations in a totally asymmetric simple exclusion process with finite resources [J].
Cook, L. Jonathan ;
Zia, R. K. P. .
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, 2009,
[10]  
COOK LJ, THESIS VIRGINIA TECH