Metastamir: The Field of Metastasis-Regulatory microRNA Is Spreading

被引：248

作者：

Hurst, Douglas R. ^{[1
,5
]}

Edmonds, Mich D. ^{[1
,5
]}

Welch, Danny R. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Alabama, Dept Pathol, Ctr Metastasis Res, Birmingham, AL 35294 USA

[2] Univ Alabama, Dept Cell Biol, Ctr Metastasis Res, Birmingham, AL 35294 USA

[3] Univ Alabama, Dept Pharmacol Toxicol, Ctr Metastasis Res, Birmingham, AL 35294 USA

[4] Univ Alabama, Ctr Comprehens Canc, Ctr Metastasis Res, Birmingham, AL 35294 USA

[5] Univ Alabama, Natl Fdn Canc Res, Ctr Metastasis Res, Birmingham, AL 35294 USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 19期

关键词：

BREAST-CANCER METASTASIS; TUMOR INVASION; EXPRESSION;

D O I：

10.1158/0008-5472.CAN-09-2111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite advancements in knowledge from more than a century of metastasis research, the genetic programs and molecular mechanisms required for cancer metastasis are still incompletely understood. Genes that specifically regulate the process of metastasis are useful tools to elucidate molecular mechanisms and may become markers and/or targets for antimetastatic therapy. Recently, several noncoding regulatory RNA genes, microRNA (miRNA), were identified, which play roles in various steps of metastasis, some without obvious roles in tumorigenesis. Understanding how these metastasis-associated miRNA, which we term metastamir, are involved in metastasis will help identify possible biomarkers or targets for the most lethal attribute of cancer: metastasis. [Cancer Res 2009;69(19):7495-8]

引用

收藏

页码：7495 / 7498

页数：4

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