Cloning and initial characterization of human and mouse Spot 14 genes

被引：27

作者：

Grillasca, JP

Gastaldi, M

Khiri, H

Dace, A

Peyrol, N

Reynier, P

Torresani, J

Planells, R

机构：

[1] FAC MED MARSEILLE,INSERM,U38,F-13385 MARSEILLE 5,FRANCE

[2] INSERM,U130,F-13009 MARSEILLE,FRANCE

[3] FAC MED MONTPELLIER,BIOCHIM CELLULAIRE LAB,F-13005 MARSEILLE,FRANCE

来源：

FEBS LETTERS | 1997年 / 401卷 / 01期

关键词：

Spot; 14; Homo sapiens; Mus musculus; promoter; G12; protein; multiple symmetric lipomatosis;

D O I：

10.1016/S0014-5793(96)01433-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intricate regulation of Spot 14 expression in rat Lipogenic tissues has provided a useful tool in studying nutritional and hormonal factors involved in transcription, To gain insight into its function and its possible involvement in human lipid disorders, we cloned human and mouse Spot 14 genes that shared with the rat gene a strong homology concerning the deduced amino acid sequence (81 and 94%, respectively) as well as the promoter region, The mouse promoter was characterized by transfection studies, while quantitative RT-PCR and in situ hybridization experiments showed that Spot 14 is expressed in human liver and, at a high level, in multiple symmetric lipomatosis nodules.

引用

页码：38 / 42

页数：5

共 36 条

[1] AN RNA POLYMERASE-II TRANSCRIPTION FACTOR BINDS TO AN UPSTREAM ELEMENT IN THE ADENOVIRUS MAJOR LATE PROMOTER [J].