Inhibition of protein kinase C counteracts TNFα-induced intercellular adhesion molecule 1 expression and fluid phase endocytosis on brain microvascular endothelial cells

被引：21

作者：

Defazio, G ^{[1
]}

Nico, B

Trojano, M

Ribatti, D

Giorelli, M

Ricchiuti, F

Martino, D

Roncali, L

Livrea, P

机构：

[1] Univ Bari, Dept Neurol & Psychiat Sci, I-70124 Bari, Italy

[2] Univ Bari, Inst Human Anat, Sect Histol, I-70124 Bari, Italy

来源：

BRAIN RESEARCH | 2000年 / 863卷 / 1-2期

关键词：

TNF alpha; protein kinase C; intercelluar adhesion molecule 1; fluid phase endocytosis; brain microvascular endothelial cell;

D O I：

10.1016/S0006-8993(00)02127-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TNF alpha (100 U/ml, 24 h) upregulated intercellular adhesion molecule 1 (ICAM1) expression and fluid phase endocytosis (FPE) of horseradish peroxidase on brain microvascular endothelial cell (BMEC) culture. The protein kinase C (PKC) inhibitor staurosporin (0.5-10 nM) antagonized ICAM1 expression and FPE due to TNF alpha, whereas the protein kinase A inhibitor H89 (0.5-10 nM) did not. These findings indicate that a PKC-dependent mechanism may affect TNFa signalling on different barrier properties of BMECs. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：245 / 248

页数：4

共 17 条

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