The role of matrix metalloproteinase 7 in innate immunity

被引：53

作者：

Burke, B ^{[1
]}

机构：

[1] Univ Leicester, Dept Infect Immun & Inflammat, Leicester LE1 9HN, Leics, England

来源：

IMMUNOBIOLOGY | 2004年 / 209卷 / 1-2期

关键词：

metalloproteinase; hypoxia; macrophages;

D O I：

10.1016/j.imbio.2004.04.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro- defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia. (C) 2004 Elsevier GmbH. All rights reserved.

引用

页码：51 / 56

页数：6

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