Synthesis of a chiral 1 beta-methylcarbapenem key intermediate using radical cyclization of N-vinylic alpha-bromo amides

被引:25
作者
Ishibashi, H
Kameoka, C
Kodama, K
Kawanami, H
Hamada, M
Ikeda, M
机构
[1] Kyoto Pharmaceutical University, Misasagi, Yamashina
[2] Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi
关键词
D O I
10.1016/S0040-4020(97)00645-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The chiral 1 beta-methylcarbapenem key intermediate 5 was synthesized by using radical cyclization of N-vinylic alpha-bromo amide 18 as a key step. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:9611 / 9622
页数:12
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