Heterodimeric adenosine receptors: a device to regulate neurotransmitter release

被引：79

作者：

Ciruela, F.

Ferre, S.

Casado, V.

Cortes, A.

Cunha, R. A.

Lluis, C.

Franco, R.

机构：

[1] Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain

[2] NIDA, Behav Neurosci Branch, Intramural Res Program, NIH,US Dept HHS, Baltimore, MD 21224 USA

[3] Univ Coimbra, Fac Med, Ctr Neurosci Coimbra, P-3004504 Coimbra, Portugal

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2006年 / 63卷 / 21期

关键词：

adenosine A(1) receptor; adenosine A(2A) receptor; heteromeric receptor; glutamatergic neurotransmission;

D O I：

10.1007/s00018-006-6216-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since 1990 it has been known that dimers are the basic functional form of nearly all G-protein-coupled receptors (GPCRs) and that homo- and heterodimerization may play a key role in correct receptor maturation and trafficking to the plasma membrane. Nevertheless, homo- and heterodimerization of GPCR has become a matter of debate especially in the search for the precise physiological meaning of this phenomenon. This article focuses on how heterodimerization of adenosine A(1) and A(2A) receptors, which are coupled to apparently opposite signalling pathways, allows adenosine to exert a fine-tuning modulation of striatal glutamatergic neurotransmission, providing a switch mechanism by which low and high concentrations of adenosine inhibit and stimulate, respectively, glutamate release.

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页码：2427 / 2431

页数：5

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