Platinum(II) complexes catalyze reactions between platinum(IV) complexes and 9-methylxanthine

被引：25

作者：

Roat, RM ^{[1
]}

Jerardi, MJ ^{[1
]}

Kopay, CB ^{[1
]}

Heath, DC ^{[1
]}

Clark, JA ^{[1
]}

DeMars, JA ^{[1
]}

Weaver, JM ^{[1
]}

Bezemer, E ^{[1
]}

Reedijk, J ^{[1
]}

机构：

[1] LEIDEN UNIV,LEIDEN INST CHEM,GORLAEUS LABS,NL-2300 RA LEIDEN,NETHERLANDS

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1997年 / 19期

关键词：

D O I：

10.1039/a703749j

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reactions between 9-methylxanthine (9-mxan) and platinum(IV) complexes having ammine, organic amine and chloro ligands are speeded up dramatically by additions of small amounts of the analogous platinum(II) complex. Complexes studied include cis-dichlorodiammineplatinum(II) {cis-[Pt(NH3)(2)Cl-2] 1a}, cis-tetrachlorodiammine-platinum(IV) {cis-[Pt(NH3)(2)Cl-4] 1b}, cis-dichloroammine(cyclohexylamine)platinum(II) {cis-[Pt(NH3)(cha)Cl-2] 2a}, cis-tetrachloroammine(cyclohexylamine)platinum(IV) {cis-[Pt(NH3)(cha)Cl-4] 2b}, chloro(diethylenetriamine)platinum(II) chloride {[Pt(dien)Cl]Cl 3a} and mer-trichloro(diethylenetriamine)platinum(IV) chloride {mer-[Pt(dien)Cl-3]Cl 3b}. For a 10:90 molar ratio of 1a:1b, the half-life for platinum(IV)-9-mxan product formation is approximately 3 h whereas t1/2 for pure 1b-9-mxan product formation is greater than 90 h, indicating a 30 times rate enhancement upon addition of 10% of the platinum(II) complex. For the 2a:2b pair, an eight-fold rate enhancement is observed over that for pure 2b-9-mxan. This behavior may be related to the chloride bridging mechanism first elucidated for platinum-(II) and -(IV) complexes. Since known platinum-(II) and -(IV) antitumor drugs target nucleobases of DNA to effect cell death in malignant cells; the reactions discussed may shed light on platinum antitumor compound reaction mechanisms.

引用

页码：3615 / 3621

页数：7

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