Passive transfer of serum antibodies induced by BBG2Na, a subunit vaccine, in the elderly protects SCID mouse lungs against respiratory syncytial virus challenge

被引:10
作者
Plotnicky-Gilquin, H
Cyblat-Chanal, D
Goetsch, L
Lacheny, C
Libon, C
Champion, T
Beck, A
Pasche, H
Nguyen, TN
Bonnefoy, JY
Bouveret-le-Cam, N
Corvaïa, N
机构
[1] Ctr Immunol Pierre Fabre, F-74164 St Julien En Genevois, France
[2] Inst Rech Pierre Fabre, Labege, France
关键词
D O I
10.1006/viro.2002.1563
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Respiratory syncytial virus (RSV) is responsible for severe low respiratory tract infections in young infants and the elderly. To investigate whether BBG2Na, a recombinant subunit vaccine comprising aa 130-230 of the RSV G protein, induced protective Abs in subjects over 60 years during phase II clinical trial, pre- and postimmunization sera of individuals immunized with BBG2Na or placebo were transferred into SCID mice before RSV challenge. These sera dose-dependently reduced lung RSV titers. However at some points of serial dilutions, postimmunization sera of BBG2Na-immunized subjects only were significantly more efficient than the corresponding preimmunization sera, in agreement with the induction of an increased Ab response against multiple epitopes on RSV-A G protein. Thus, BBG2Na is immunogenic in the elderly and confers passive protection in mice after serum transfer. To our knowledge, this is the first description of protective Abs induced by a subunit vaccine in human. (C) 2002 Elsevier Science (USA).
引用
收藏
页码:130 / 137
页数:8
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