Characterization of nucleic acids by nanopore analysis

被引：412

作者：

Deamer, DW ^{[1
]}

Branton, D

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Harvard Univ, Biol Labs, Cambridge, MA 02138 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2002年 / 35卷 / 10期

关键词：

D O I：

10.1021/ar000138m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.

引用

页码：817 / 825

页数：9

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