Structure-activity relationship studies of flavopiridol analogues

被引：52

作者：

Murthi, KK

Dubay, M

McClure, C

Brizuela, L

Boisclair, MD

Worland, PJ

Mansuri, MM

Pal, K

机构：

[1] Mitotix Inc, Dept Med Chem, Cambridge, MA 02139 USA

[2] Mitotix Inc, Dept Biochem, Cambridge, MA 02139 USA

[3] Mitotix Inc, Dept Screening, Cambridge, MA 02139 USA

[4] Mitotix Inc, Dept Pharmacol, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)00156-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1037 / 1041

页数：5

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