Vancomycin-resistant enterococci in humans and imported chickens in Japan

被引：26

作者：

Ozawa, Y

Tanimoto, K

Nomura, T

Yoshinaga, M

Arakawa, Y

Ike, Y

机构：

[1] Gunma Univ, Sch Med, Dept Microbiol, Maebashi, Gumma 3718511, Japan

[2] Gunma Univ, Sch Med, Lab Bacterial Drug Resistance, Maebashi, Gumma 3718511, Japan

[3] Kagoshima Univ Hosp, Infect Control Team, Kagoshima, Japan

[4] Kagoshima Univ, Sch Med, Dept Pediat, Kagoshima 8908520, Japan

[5] Natl Inst Infect Dis, Dept Bacterial & Blood Prod, Tokyo 2080011, Japan

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2002年 / 68卷 / 12期

关键词：

D O I：

10.1128/AEM.68.12.6457-6461.2002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The phenotypes and genotypes of 22 VanA-type vancomycin-resistant enterococci that had been isolated in Japan were examined. The VanA resistance determinant was plasmid mediated in each of the 22 strains. Of the 22 strains, 8 were isolated from different patients and 11 and 3 were obtained from different samples of chickens imported from Thailand and France, respectively. Three of the strains that were isolated from patients and the It strains isolated from the Thai chickens showed high-level vancomycin resistance (MICs, 512 to 1,024 mug/ml) and low-level teicoplanin resistance (MICs, 0.5 to 4 mug/ml). Each of these strains had three amino acid substitutions in the N-terminal region of the deduced VanS sequence. L50 was converted to V, E54 was converted to Q, and Q69 was converted to H compared to the vanS gene sequence of Tn1546.

引用

页码：6457 / 6461

页数：5

共 18 条

[1] THE VANS-VANR 2-COMPONENT REGULATORY SYSTEM CONTROLS SYNTHESIS OF DEPSIPEPTIDE PEPTIDOGLYCAN PRECURSORS IN ENTEROCOCCUS-FAECIUM BM4147 [J].