Nonfibrinolytic functions of plasminogen

被引:28
作者
Ploplis, VA [1 ]
Castellino, FJ
机构
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
[2] Univ Notre Dame, WM Keck Ctr Transgene Res, Notre Dame, IN 46556 USA
来源
METHODS-A COMPANION TO METHODS IN ENZYMOLOGY | 2000年 / 21卷 / 02期
关键词
plasminogen deficiency; inflammation; cell migration;
D O I
10.1006/meth.2000.0981
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Although the roles of plasminogen and plasmin in mediating blood clot dissolution are well known, the availability of mice deficient for components of the fibrinolytic system has allowed direct approaches to be made toward elucidating the role of these proteins in other diverse physiological and pathophysiological processes. A number of these studies have identified plasminogen as playing an important role in inflammation and other cell migratory processes. With the identification of receptors for plasminogen on a number of pathogens, and the ability to activate plasminogen through either endogenous production of plasminogen activators or utilization of host activators, mice deficient for components of the fibrinolytic system offer a unique approach toward further elucidating the importance of this system in pathogen infection and dissemination. (C) 2000 Academic Press.
引用
收藏
页码:103 / 110
页数:8
相关论文
共 86 条
[1]  
BERGE A, 1993, J BIOL CHEM, V268, P25417
[2]   PLASMINOGEN DEFICIENCY CAUSES SEVERE THROMBOSIS BUT IS COMPATIBLE WITH DEVELOPMENT AND REPRODUCTION [J].
BUGGE, TH ;
FLICK, MJ ;
DAUGHERTY, CC ;
DEGEN, JL .
GENES & DEVELOPMENT, 1995, 9 (07) :794-807
[3]   Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency [J].
Bugge, TH ;
Kombrinck, KW ;
Flick, MJ ;
Daugherty, CC ;
Danton, MJS ;
Degen, JL .
CELL, 1996, 87 (04) :709-719
[4]   Expression, isolation and characterization of a mutated human plasminogen kringle 3 with a functional lysine binding site [J].
Bürgin, J ;
Schaller, J .
CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (01) :135-141
[5]   SOLUTION STRUCTURE OF THE TISSUE-TYPE PLASMINOGEN-ACTIVATOR KRINGLE-2 DOMAIN COMPLEXED TO 6-AMINOHEXANOIC ACID AN ANTIFIBRINOLYTIC DRUG [J].
BYEON, IJL ;
LLINAS, M .
JOURNAL OF MOLECULAR BIOLOGY, 1991, 222 (04) :1035-1051
[6]   Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen [J].
Chang, Y ;
Mochalkin, I ;
McCance, SG ;
Cheng, BS ;
Tulinsky, A ;
Castellino, FJ .
BIOCHEMISTRY, 1998, 37 (10) :3258-3271
[7]   MACROPHAGE FIBRINOLYTIC-ACTIVITY - IDENTIFICATION OF 2 PATHWAYS OF PLASMIN FORMATION BY INTACT-CELLS AND OF A PLASMINOGEN-ACTIVATOR INHIBITOR [J].
CHAPMAN, HA ;
VAVRIN, Z ;
HIBBS, JB .
CELL, 1982, 28 (03) :653-662
[8]   Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin [J].
Chen, ZL ;
Strickland, S .
CELL, 1997, 91 (07) :917-925
[9]   Interaction of a group A Streptococcus within human plasma results in assembly of a surface plasminogen activator that contributes to occupancy of surface plasmin-binding structures [J].
D'Costa, SS ;
Boyle, MDP .
MICROBIAL PATHOGENESIS, 1998, 24 (06) :341-349
[10]   PLASMINOGEN ACTIVATORS, TISSUE DEGRADATION, AND CANCER [J].
DANO, K ;
ANDREASEN, PA ;
GRONDAHLHANSEN, J ;
KRISTENSEN, P ;
NIELSEN, LS ;
SKRIVER, L .
ADVANCES IN CANCER RESEARCH, 1985, 44 :139-266